ZNF664 protein (human) - STRING database

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ZNF664

Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type (261 aa)

Predicted Functional Partners:

TRIM28

0.903

DNAH10

0.656

CCDC92

0.642

CNBD2

0.577

ARL15

0.568

NT5DC2

0.557

TRIB1

0.547

BTNL2

0.545

CCDC62

0.534

PCCB

0.532

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL15	NT5DC2	ENSP00000433427	ENSP00000406933	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	5’-nucleotidase domain containing 2	0.480
ARL15	ZNF664	ENSP00000433427	ENSP00000441405	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.568
BTNL2	ZNF664	ENSP00000390613	ENSP00000441405	Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.545
CCDC62	ZNF664	ENSP00000253079	ENSP00000441405	Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.534
CCDC92	DNAH10	ENSP00000238156	ENSP00000386770	Coiled-coil domain containing 92	Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain	0.685
CCDC92	NT5DC2	ENSP00000238156	ENSP00000406933	Coiled-coil domain containing 92	5’-nucleotidase domain containing 2	0.462
CCDC92	ZNF664	ENSP00000238156	ENSP00000441405	Coiled-coil domain containing 92	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.642
CNBD2	ZNF664	ENSP00000340954	ENSP00000441405	Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.577
DNAH10	CCDC92	ENSP00000386770	ENSP00000238156	Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain	Coiled-coil domain containing 92	0.685
DNAH10	NT5DC2	ENSP00000386770	ENSP00000406933	Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain	5’-nucleotidase domain containing 2	0.435
DNAH10	ZNF664	ENSP00000386770	ENSP00000441405	Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.656
NT5DC2	ARL15	ENSP00000406933	ENSP00000433427	5’-nucleotidase domain containing 2	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	0.480
NT5DC2	CCDC92	ENSP00000406933	ENSP00000238156	5’-nucleotidase domain containing 2	Coiled-coil domain containing 92	0.462
NT5DC2	DNAH10	ENSP00000406933	ENSP00000386770	5’-nucleotidase domain containing 2	Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain	0.435
NT5DC2	ZNF664	ENSP00000406933	ENSP00000441405	5’-nucleotidase domain containing 2	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.557
PCCB	ZNF664	ENSP00000419027	ENSP00000441405	propionyl-CoA carboxylase beta subunit	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.532
TRIB1	ZNF664	ENSP00000312150	ENSP00000441405	Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase. The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2- dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Int [...]	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.547
TRIM28	ZNF664	ENSP00000253024	ENSP00000441405	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.903
ZNF664	ARL15	ENSP00000441405	ENSP00000433427	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	0.568
ZNF664	BTNL2	ENSP00000441405	ENSP00000390613	Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family	0.545

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