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  • 11.0 [archived version]
STRINGSTRING
TOMM70A TOMM70A GRAMD1B GRAMD1B HPN HPN GRAMD1A GRAMD1A GPATCH2 GPATCH2 PSMC4 PSMC4 AGAP6 AGAP6 ANKRD31 ANKRD31 AGAP4 AGAP4 ZNF620 ZNF620 NOC3L NOC3L
"GRAMD1A" - GRAM domain-containing protein 1A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRAMD1AGRAM domain-containing protein 1A; May play a role in tumor progression; GRAM domain containing (724 aa)    
Predicted Functional Partners:
GRAMD1B
GRAM domain containing 1B (745 aa)
        
 
0.744
AGAP6
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Ankyrin repeat domain containing (686 aa)
      
   
  0.649
HPN
Serine protease hepsin; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2. Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization; Belongs to the peptidase S1 family (417 aa)
            
  0.639
TOMM70A
Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins (608 aa)
        
 
  0.568
ZNF620
Zinc finger protein 620; May be involved in transcriptional regulation; Zinc fingers C2H2-type (422 aa)
      
   
  0.565
PSMC4
26S proteasome regulatory subunit 6B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated wit [...] (418 aa)
      
 
  0.560
ANKRD31
Putative ankyrin repeat domain-containing protein 31; Ankyrin repeat domain containing (1873 aa)
            
  0.559
GPATCH2
G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing (528 aa)
      
   
  0.527
AGAP4
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Ankyrin repeat domain containing (663 aa)
      
   
  0.510
NOC3L
Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing (800 aa)
            
  0.498
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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