node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD4 | GDE1 | ENSP00000414558 | ENSP00000261386 | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] | Glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | 0.839 |
ABHD4 | PLD5 | ENSP00000414558 | ENSP00000440896 | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | 0.496 |
CEP170 | KBTBD2 | ENSP00000355500 | ENSP00000302586 | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family | Kelch repeat and BTB domain containing 2 | 0.416 |
CEP170 | PLD5 | ENSP00000355500 | ENSP00000440896 | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | 0.712 |
CEP170 | ZBTB18 | ENSP00000355500 | ENSP00000351539 | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5’- [AC]ACATCTG[GT][AC]-3’ which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...] | 0.736 |
CTTNBP2NL | KBTBD2 | ENSP00000271277 | ENSP00000302586 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex | Kelch repeat and BTB domain containing 2 | 0.544 |
CTTNBP2NL | PLD5 | ENSP00000271277 | ENSP00000440896 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | 0.477 |
GDE1 | ABHD4 | ENSP00000261386 | ENSP00000414558 | Glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] | 0.839 |
GDE1 | PLD5 | ENSP00000261386 | ENSP00000440896 | Glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | 0.530 |
KBTBD2 | CEP170 | ENSP00000302586 | ENSP00000355500 | Kelch repeat and BTB domain containing 2 | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family | 0.416 |
KBTBD2 | CTTNBP2NL | ENSP00000302586 | ENSP00000271277 | Kelch repeat and BTB domain containing 2 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex | 0.544 |
KBTBD2 | PLD5 | ENSP00000302586 | ENSP00000440896 | Kelch repeat and BTB domain containing 2 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | 0.545 |
PLD2 | PLD5 | ENSP00000263088 | ENSP00000440896 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis; Phospholipases | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | 0.531 |
PLD2 | PLD6 | ENSP00000263088 | ENSP00000317177 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis; Phospholipases | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI- interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). A [...] | 0.467 |
PLD5 | ABHD4 | ENSP00000440896 | ENSP00000414558 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] | 0.496 |
PLD5 | CEP170 | ENSP00000440896 | ENSP00000355500 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family | 0.712 |
PLD5 | CTTNBP2NL | ENSP00000440896 | ENSP00000271277 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex | 0.477 |
PLD5 | GDE1 | ENSP00000440896 | ENSP00000261386 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | Glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity) | 0.530 |
PLD5 | KBTBD2 | ENSP00000440896 | ENSP00000302586 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | Kelch repeat and BTB domain containing 2 | 0.545 |
PLD5 | PLD2 | ENSP00000440896 | ENSP00000263088 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis; Phospholipases | 0.531 |