node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHNAK | CAPN9 | ENSP00000367263 | ENSP00000271971 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | 0.701 |
AHNAK | EVPL | ENSP00000367263 | ENSP00000301607 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins | 0.916 |
AHNAK | PPL | ENSP00000367263 | ENSP00000340510 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family | 0.878 |
AHNAK | ZNF185 | ENSP00000367263 | ENSP00000440847 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing | Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing | 0.837 |
CAPN9 | AHNAK | ENSP00000271971 | ENSP00000367263 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing | 0.701 |
CAPN9 | EVPL | ENSP00000271971 | ENSP00000301607 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins | 0.917 |
CAPN9 | PPL | ENSP00000271971 | ENSP00000340510 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family | 0.765 |
CAPN9 | ZNF185 | ENSP00000271971 | ENSP00000440847 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing | 0.738 |
CYP3A4 | ZNF185 | ENSP00000337915 | ENSP00000440847 | Cytochrome P450 3A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1’-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of chol [...] | Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing | 0.542 |
EVPL | AHNAK | ENSP00000301607 | ENSP00000367263 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing | 0.916 |
EVPL | CAPN9 | ENSP00000301607 | ENSP00000271971 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | 0.917 |
EVPL | GAS2 | ENSP00000301607 | ENSP00000401145 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins | Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity) | 0.527 |
EVPL | PPL | ENSP00000301607 | ENSP00000340510 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family | 0.996 |
EVPL | ZNF185 | ENSP00000301607 | ENSP00000440847 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins | Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing | 0.879 |
GAS2 | EVPL | ENSP00000401145 | ENSP00000301607 | Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity) | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins | 0.527 |
GAS2 | PPL | ENSP00000401145 | ENSP00000340510 | Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity) | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family | 0.438 |
GAS2 | ZNF185 | ENSP00000401145 | ENSP00000440847 | Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity) | Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing | 0.519 |
IFI27 | ZNF185 | ENSP00000483430 | ENSP00000440847 | Interferon alpha-inducible protein 27, mitochondrial; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 | Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing | 0.544 |
PPL | AHNAK | ENSP00000340510 | ENSP00000367263 | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing | 0.878 |
PPL | CAPN9 | ENSP00000340510 | ENSP00000271971 | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | 0.765 |