node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSM5 | CACFD1 | ENSP00000327916 | ENSP00000440832 | Acyl-coenzyme A synthetase ACSM5, mitochondrial; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family | Calcium channel flower domain containing 1 | 0.568 |
ACSM5 | IGLL5 | ENSP00000327916 | ENSP00000431254 | Acyl-coenzyme A synthetase ACSM5, mitochondrial; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family | Immunoglobulin lambda like polypeptide 5; C1-set domain containing | 0.503 |
C9orf72 | CACFD1 | ENSP00000482753 | ENSP00000440832 | Guanine nucleotide exchange C9orf72; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity. Positively [...] | Calcium channel flower domain containing 1 | 0.512 |
CACFD1 | ACSM5 | ENSP00000440832 | ENSP00000327916 | Calcium channel flower domain containing 1 | Acyl-coenzyme A synthetase ACSM5, mitochondrial; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family | 0.568 |
CACFD1 | C9orf72 | ENSP00000440832 | ENSP00000482753 | Calcium channel flower domain containing 1 | Guanine nucleotide exchange C9orf72; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity. Positively [...] | 0.512 |
CACFD1 | IGLL5 | ENSP00000440832 | ENSP00000431254 | Calcium channel flower domain containing 1 | Immunoglobulin lambda like polypeptide 5; C1-set domain containing | 0.626 |
CACFD1 | MAP6D1 | ENSP00000440832 | ENSP00000314560 | Calcium channel flower domain containing 1 | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family | 0.536 |
CACFD1 | MAPRE1 | ENSP00000440832 | ENSP00000364721 | Calcium channel flower domain containing 1 | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization- interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, [...] | 0.712 |
CACFD1 | PCMTD1 | ENSP00000440832 | ENSP00000353739 | Calcium channel flower domain containing 1 | protein-L-isoaspartate O-methyltransferase domain containing 1; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family | 0.801 |
CACFD1 | PCMTD2 | ENSP00000440832 | ENSP00000307854 | Calcium channel flower domain containing 1 | protein-L-isoaspartate O-methyltransferase domain containing 2; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family | 0.451 |
CACFD1 | PNOC | ENSP00000440832 | ENSP00000301908 | Calcium channel flower domain containing 1 | Prepronociceptin; Nociceptin- Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development; Belongs to the opioid neuropeptide precursor family | 0.468 |
CACFD1 | TMEM159 | ENSP00000440832 | ENSP00000233047 | Calcium channel flower domain containing 1 | Promethin; Transmembrane protein 159; Belongs to the TMEM159 family | 0.686 |
CACFD1 | TMEM8C | ENSP00000440832 | ENSP00000419712 | Calcium channel flower domain containing 1 | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction. Associates with MYMX to promote myoblast fusion; Belongs to the TMEM8 family | 0.473 |
IGLL5 | ACSM5 | ENSP00000431254 | ENSP00000327916 | Immunoglobulin lambda like polypeptide 5; C1-set domain containing | Acyl-coenzyme A synthetase ACSM5, mitochondrial; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family | 0.503 |
IGLL5 | CACFD1 | ENSP00000431254 | ENSP00000440832 | Immunoglobulin lambda like polypeptide 5; C1-set domain containing | Calcium channel flower domain containing 1 | 0.626 |
IGLL5 | PNOC | ENSP00000431254 | ENSP00000301908 | Immunoglobulin lambda like polypeptide 5; C1-set domain containing | Prepronociceptin; Nociceptin- Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development; Belongs to the opioid neuropeptide precursor family | 0.530 |
MAP6D1 | CACFD1 | ENSP00000314560 | ENSP00000440832 | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family | Calcium channel flower domain containing 1 | 0.536 |
MAPRE1 | CACFD1 | ENSP00000364721 | ENSP00000440832 | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization- interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, [...] | Calcium channel flower domain containing 1 | 0.712 |
MAPRE1 | PCMTD1 | ENSP00000364721 | ENSP00000353739 | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization- interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, [...] | protein-L-isoaspartate O-methyltransferase domain containing 1; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family | 0.673 |
PCMTD1 | CACFD1 | ENSP00000353739 | ENSP00000440832 | protein-L-isoaspartate O-methyltransferase domain containing 1; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family | Calcium channel flower domain containing 1 | 0.801 |