• Version:
  • 11.0 [archived version]
STRINGSTRING
TMEM8C TMEM8C C9orf72 C9orf72 MAP6D1 MAP6D1 TMEM159 TMEM159 PCMTD2 PCMTD2 CACFD1 CACFD1 ACSM5 ACSM5 MAPRE1 MAPRE1 IGLL5 IGLL5 PCMTD1 PCMTD1 PNOC PNOC
"CACFD1" - Calcium channel flower domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CACFD1Calcium channel flower domain containing 1 (233 aa)    
Predicted Functional Partners:
PCMTD1
protein-L-isoaspartate O-methyltransferase domain containing 1; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family (357 aa)
           
  0.801
MAPRE1
Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization- interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, [...] (268 aa)
           
  0.712
TMEM159
Promethin; Transmembrane protein 159; Belongs to the TMEM159 family (161 aa)
       
      0.686
IGLL5
Immunoglobulin lambda like polypeptide 5; C1-set domain containing (214 aa)
           
  0.626
ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family (579 aa)
           
  0.568
MAP6D1
MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family (199 aa)
           
  0.536
C9orf72
Guanine nucleotide exchange C9orf72; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity. Positively [...] (481 aa)
           
  0.512
TMEM8C
Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction. Associates with MYMX to promote myoblast fusion; Belongs to the TMEM8 family (221 aa)
           
  0.473
PNOC
Prepronociceptin; Nociceptin- Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development; Belongs to the opioid neuropeptide precursor family (176 aa)
           
  0.468
PCMTD2
protein-L-isoaspartate O-methyltransferase domain containing 2; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family (361 aa)
           
  0.451
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]