• Version:
  • 11.0 [archived version]
STRINGSTRING
DDI2 DDI2 LEPROT LEPROT CRYZL1 CRYZL1 PAXBP1 PAXBP1 TMEM50B TMEM50B MRPS6 MRPS6 LEPROTL1 LEPROTL1 DOPEY2 DOPEY2 DONSON DONSON GART GART DSCR3 DSCR3
"TMEM50B" - Transmembrane protein 50B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM50BTransmembrane protein 50B (158 aa)    
Predicted Functional Partners:
DONSON
Protein downstream neighbor of Son; Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra- S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability (566 aa)
     
   
  0.751
LEPROTL1
Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family (169 aa)
     
 
  0.710
MRPS6
Mitochondrial ribosomal protein S6 (125 aa)
           
  0.705
CRYZL1
Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily (349 aa)
     
   
  0.697
LEPROT
Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (140 aa)
     
 
  0.667
DOPEY2
Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family (2298 aa)
           
  0.604
PAXBP1
PAX3- and PAX7-binding protein 1; Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of ’Lys-4’ of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity) (917 aa)
           
  0.579
DSCR3
Down syndrome critical region gene 3; Belongs to the VPS26 family (297 aa)
           
  0.563
GART
Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family (1010 aa)
           
  0.545
DDI2
DNA damage inducible 1 homolog 2; Belongs to the DDI1 family (399 aa)
           
  0.545
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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