node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP6V1B1 | ATP6V1C2 | ENSP00000234396 | ENSP00000272238 | V-type proton ATPase subunit B, kidney isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family | V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | 0.999 |
ATP6V1B1 | ATP6V1E1 | ENSP00000234396 | ENSP00000253413 | V-type proton ATPase subunit B, kidney isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family | V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | 0.999 |
ATP6V1B1 | DMXL1 | ENSP00000234396 | ENSP00000439479 | V-type proton ATPase subunit B, kidney isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family | DmX-like protein 1; WD repeat domain containing | 0.902 |
ATP6V1C2 | ATP6V1B1 | ENSP00000272238 | ENSP00000234396 | V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | V-type proton ATPase subunit B, kidney isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family | 0.999 |
ATP6V1C2 | ATP6V1E1 | ENSP00000272238 | ENSP00000253413 | V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | 0.998 |
ATP6V1C2 | DMXL1 | ENSP00000272238 | ENSP00000439479 | V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | DmX-like protein 1; WD repeat domain containing | 0.832 |
ATP6V1E1 | ATP6V1B1 | ENSP00000253413 | ENSP00000234396 | V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | V-type proton ATPase subunit B, kidney isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family | 0.999 |
ATP6V1E1 | ATP6V1C2 | ENSP00000253413 | ENSP00000272238 | V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | 0.998 |
ATP6V1E1 | DMXL1 | ENSP00000253413 | ENSP00000439479 | V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | DmX-like protein 1; WD repeat domain containing | 0.650 |
BDP1 | DMXL1 | ENSP00000351575 | ENSP00000439479 | Transcription factor TFIIIB component B’’ homolog; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site; Myb/SANT domain containing | DmX-like protein 1; WD repeat domain containing | 0.839 |
BDP1 | PHIP | ENSP00000351575 | ENSP00000275034 | Transcription factor TFIIIB component B’’ homolog; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site; Myb/SANT domain containing | PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti- apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization; Bromodomain containing | 0.845 |
DMXL1 | ATP6V1B1 | ENSP00000439479 | ENSP00000234396 | DmX-like protein 1; WD repeat domain containing | V-type proton ATPase subunit B, kidney isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family | 0.902 |
DMXL1 | ATP6V1C2 | ENSP00000439479 | ENSP00000272238 | DmX-like protein 1; WD repeat domain containing | V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | 0.832 |
DMXL1 | ATP6V1E1 | ENSP00000439479 | ENSP00000253413 | DmX-like protein 1; WD repeat domain containing | V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; V-type ATPases | 0.650 |
DMXL1 | BDP1 | ENSP00000439479 | ENSP00000351575 | DmX-like protein 1; WD repeat domain containing | Transcription factor TFIIIB component B’’ homolog; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site; Myb/SANT domain containing | 0.839 |
DMXL1 | NKTR | ENSP00000439479 | ENSP00000232978 | DmX-like protein 1; WD repeat domain containing | NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases | 0.680 |
DMXL1 | PHIP | ENSP00000439479 | ENSP00000275034 | DmX-like protein 1; WD repeat domain containing | PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti- apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization; Bromodomain containing | 0.666 |
DMXL1 | RAB3GAP1 | ENSP00000439479 | ENSP00000411418 | DmX-like protein 1; WD repeat domain containing | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | 0.654 |
DMXL1 | RAB3GAP2 | ENSP00000439479 | ENSP00000351832 | DmX-like protein 1; WD repeat domain containing | Rab3 GTPase-activating protein non-catalytic subunit; Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters | 0.660 |
DMXL1 | SKP1 | ENSP00000439479 | ENSP00000231487 | DmX-like protein 1; WD repeat domain containing | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.696 |