node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HTN3 | ZNF133 | ENSP00000432561 | ENSP00000439427 | Histatin-3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.629 |
LGALS4 | ZNF133 | ENSP00000302100 | ENSP00000439427 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.537 |
MRPS2 | TPD52 | ENSP00000360850 | ENSP00000429309 | Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family | Tumor protein D52 | 0.835 |
MRPS2 | ZNF133 | ENSP00000360850 | ENSP00000439427 | Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.782 |
PIAS1 | ZNF133 | ENSP00000249636 | ENSP00000439427 | E3 SUMO-protein ligase PIAS1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in th [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.580 |
POLR3F | RBBP9 | ENSP00000366828 | ENSP00000336866 | DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRN [...] | Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family | 0.776 |
POLR3F | ZNF133 | ENSP00000366828 | ENSP00000439427 | DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRN [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.551 |
RBBP9 | POLR3F | ENSP00000336866 | ENSP00000366828 | Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family | DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRN [...] | 0.776 |
RBBP9 | ZNF133 | ENSP00000336866 | ENSP00000439427 | Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.587 |
SAV1 | STK4 | ENSP00000324729 | ENSP00000361892 | Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleu [...] | Serine/threonine-protein kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein [...] | 0.998 |
SAV1 | ZNF133 | ENSP00000324729 | ENSP00000439427 | Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleu [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.665 |
STK4 | SAV1 | ENSP00000361892 | ENSP00000324729 | Serine/threonine-protein kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein [...] | Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleu [...] | 0.998 |
STK4 | ZNF133 | ENSP00000361892 | ENSP00000439427 | Serine/threonine-protein kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.542 |
TPD52 | MRPS2 | ENSP00000429309 | ENSP00000360850 | Tumor protein D52 | Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family | 0.835 |
TPD52 | ZNF133 | ENSP00000429309 | ENSP00000439427 | Tumor protein D52 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.558 |
TRIM28 | ZNF133 | ENSP00000253024 | ENSP00000439427 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | 0.941 |
ZNF133 | HTN3 | ENSP00000439427 | ENSP00000432561 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | Histatin-3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 | 0.629 |
ZNF133 | LGALS4 | ENSP00000439427 | ENSP00000302100 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins | 0.537 |
ZNF133 | MRPS2 | ENSP00000439427 | ENSP00000360850 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family | 0.782 |
ZNF133 | PIAS1 | ENSP00000439427 | ENSP00000249636 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type | E3 SUMO-protein ligase PIAS1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in th [...] | 0.580 |