| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FBXL12 | RBM14 | ENSP00000247977 | ENSP00000311747 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) [...] | 0.452 |
| FBXL12 | TBC1D21 | ENSP00000247977 | ENSP00000300504 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.569 |
| FBXL12 | ZNF426 | ENSP00000247977 | ENSP00000439017 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.475 |
| KRT1 | ZNF426 | ENSP00000252244 | ENSP00000439017 | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.441 |
| LRRC57 | ZNF426 | ENSP00000326817 | ENSP00000439017 | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.451 |
| PNMA3 | ZNF426 | ENSP00000469445 | ENSP00000439017 | Paraneoplastic Ma antigens; Belongs to the PNMA family | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.524 |
| PNMA5 | WFDC12 | ENSP00000388850 | ENSP00000361871 | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | 0.537 |
| PNMA5 | ZNF426 | ENSP00000388850 | ENSP00000439017 | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.583 |
| RBM14 | FBXL12 | ENSP00000311747 | ENSP00000247977 | RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) [...] | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | 0.452 |
| RBM14 | TBC1D21 | ENSP00000311747 | ENSP00000300504 | RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) [...] | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.412 |
| RBM14 | ZNF426 | ENSP00000311747 | ENSP00000439017 | RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) [...] | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.452 |
| TBC1D21 | FBXL12 | ENSP00000300504 | ENSP00000247977 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | 0.569 |
| TBC1D21 | RBM14 | ENSP00000300504 | ENSP00000311747 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) [...] | 0.412 |
| TBC1D21 | ZNF426 | ENSP00000300504 | ENSP00000439017 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.464 |
| TRIM28 | ZNF426 | ENSP00000253024 | ENSP00000439017 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.933 |
| WFDC12 | PNMA5 | ENSP00000361871 | ENSP00000388850 | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | 0.537 |
| WFDC12 | ZNF426 | ENSP00000361871 | ENSP00000439017 | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.440 |
| ZNF385B | ZNF426 | ENSP00000386845 | ENSP00000439017 | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.463 |
| ZNF426 | FBXL12 | ENSP00000439017 | ENSP00000247977 | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | 0.475 |
| ZNF426 | KRT1 | ENSP00000439017 | ENSP00000252244 | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II | 0.441 |
