| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM107B | NOVA1 | ENSP00000181796 | ENSP00000438875 | Protein FAM107B; Family with sequence similarity 107 member B | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | 0.711 |
| FAM107B | NOVA2 | ENSP00000181796 | ENSP00000263257 | Protein FAM107B; Family with sequence similarity 107 member B | RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA | 0.648 |
| FAM107B | PTBP1 | ENSP00000181796 | ENSP00000349428 | Protein FAM107B; Family with sequence similarity 107 member B | Polypyrimidine tract-binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornav [...] | 0.426 |
| FAM107B | PTBP2 | ENSP00000181796 | ENSP00000359216 | Protein FAM107B; Family with sequence similarity 107 member B | Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA | 0.429 |
| FAM107B | RBFOX1 | ENSP00000181796 | ENSP00000309117 | Protein FAM107B; Family with sequence similarity 107 member B | RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis | 0.424 |
| FAM107B | RBFOX2 | ENSP00000181796 | ENSP00000413035 | Protein FAM107B; Family with sequence similarity 107 member B | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Prevents binding of U2AF2 to the 3’-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha | 0.535 |
| GRIA2 | NOVA1 | ENSP00000296526 | ENSP00000438875 | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | 0.784 |
| GRIA2 | NOVA2 | ENSP00000296526 | ENSP00000263257 | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA | 0.562 |
| GRIA2 | NRXN2 | ENSP00000296526 | ENSP00000265459 | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling; Neurexins | 0.576 |
| GRIA2 | NRXN3 | ENSP00000296526 | ENSP00000451648 | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | Neurexin-3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling; Neurexins | 0.520 |
| GRIA2 | RBFOX1 | ENSP00000296526 | ENSP00000309117 | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis | 0.462 |
| HNRNPM | NOVA1 | ENSP00000325376 | ENSP00000438875 | Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | 0.764 |
| HNRNPM | NOVA2 | ENSP00000325376 | ENSP00000263257 | Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA | 0.520 |
| HNRNPM | PTBP1 | ENSP00000325376 | ENSP00000349428 | Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | Polypyrimidine tract-binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornav [...] | 0.997 |
| HNRNPM | RBFOX1 | ENSP00000325376 | ENSP00000309117 | Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis | 0.517 |
| HNRNPM | RBFOX2 | ENSP00000325376 | ENSP00000413035 | Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Prevents binding of U2AF2 to the 3’-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha | 0.952 |
| NOVA1 | FAM107B | ENSP00000438875 | ENSP00000181796 | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | Protein FAM107B; Family with sequence similarity 107 member B | 0.711 |
| NOVA1 | GRIA2 | ENSP00000438875 | ENSP00000296526 | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | 0.784 |
| NOVA1 | HNRNPM | ENSP00000438875 | ENSP00000325376 | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | 0.764 |
| NOVA1 | NOVA2 | ENSP00000438875 | ENSP00000263257 | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA | 0.747 |
