• Version:
  • 11.0 [archived version]
STRINGSTRING
XAGE1B XAGE1B XAGE1A XAGE1A FYB FYB CSAG1 CSAG1 TKTL1 TKTL1 OR51B4 OR51B4 MAGEA8 MAGEA8 TDRD7 TDRD7 ZNF224 ZNF224 DUSP21 DUSP21 CCDC59 CCDC59
"MAGEA8" - Melanoma-associated antigen 8 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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MAGEA8Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family (318 aa)    
Predicted Functional Partners:
TDRD7
Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes- probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis; Belongs to the TDRD7 family (1098 aa)
       
      0.723
CSAG1
Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 (78 aa)
     
   
  0.685
ZNF224
Zinc finger protein 224; May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells; Belongs to the krueppel C2H2-type zinc-finger protein family (707 aa)
       
      0.548
CCDC59
Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities (241 aa)
       
      0.548
XAGE1B
X antigen family member 1B; Belongs to the GAGE family (81 aa)
     
   
  0.486
XAGE1A
X antigen family member 1A (81 aa)
     
   
  0.486
DUSP21
Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily (190 aa)
     
   
  0.477
FYB
FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (829 aa)
           
  0.438
TKTL1
Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (596 aa)
           
  0.426
OR51B4
Olfactory receptor 51B4; Odorant receptor; Olfactory receptors, family 51 (310 aa)
     
   
  0.414
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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