node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC59 | MAGEA8 | ENSP00000256151 | ENSP00000438293 | Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.548 |
CSAG1 | MAGEA8 | ENSP00000359310 | ENSP00000438293 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.685 |
CSAG1 | XAGE1A | ENSP00000359310 | ENSP00000364752 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 | X antigen family member 1A | 0.445 |
CSAG1 | XAGE1B | ENSP00000359310 | ENSP00000364766 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 | X antigen family member 1B; Belongs to the GAGE family | 0.441 |
DUSP21 | MAGEA8 | ENSP00000343244 | ENSP00000438293 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.477 |
FYB | MAGEA8 | ENSP00000427114 | ENSP00000438293 | FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.438 |
MAGEA8 | CCDC59 | ENSP00000438293 | ENSP00000256151 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | 0.548 |
MAGEA8 | CSAG1 | ENSP00000438293 | ENSP00000359310 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 | 0.685 |
MAGEA8 | DUSP21 | ENSP00000438293 | ENSP00000343244 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.477 |
MAGEA8 | FYB | ENSP00000438293 | ENSP00000427114 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton | 0.438 |
MAGEA8 | OR51B4 | ENSP00000438293 | ENSP00000369573 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Olfactory receptor 51B4; Odorant receptor; Olfactory receptors, family 51 | 0.414 |
MAGEA8 | TDRD7 | ENSP00000438293 | ENSP00000347444 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes- probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis; Belongs to the TDRD7 family | 0.723 |
MAGEA8 | TKTL1 | ENSP00000438293 | ENSP00000358931 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate | 0.426 |
MAGEA8 | XAGE1A | ENSP00000438293 | ENSP00000364752 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | X antigen family member 1A | 0.486 |
MAGEA8 | XAGE1B | ENSP00000438293 | ENSP00000364766 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | X antigen family member 1B; Belongs to the GAGE family | 0.486 |
MAGEA8 | ZNF224 | ENSP00000438293 | ENSP00000337368 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Zinc finger protein 224; May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.548 |
OR51B4 | MAGEA8 | ENSP00000369573 | ENSP00000438293 | Olfactory receptor 51B4; Odorant receptor; Olfactory receptors, family 51 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.414 |
TDRD7 | MAGEA8 | ENSP00000347444 | ENSP00000438293 | Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes- probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis; Belongs to the TDRD7 family | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.723 |
TKTL1 | MAGEA8 | ENSP00000358931 | ENSP00000438293 | Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.426 |
XAGE1A | CSAG1 | ENSP00000364752 | ENSP00000359310 | X antigen family member 1A | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 | 0.445 |