| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC10 | LRIT2 | ENSP00000319412 | ENSP00000438264 | Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53; Armadillo repeat containing | Leucine rich repeat, Ig-like and transmembrane domains 2; I-set domain containing | 0.646 |
| C10orf99 | HPCAL1 | ENSP00000361199 | ENSP00000483786 | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G- protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest | Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family | 0.424 |
| C10orf99 | LRIT1 | ENSP00000361199 | ENSP00000361177 | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G- protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing | 0.580 |
| C10orf99 | LRIT2 | ENSP00000361199 | ENSP00000438264 | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G- protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest | Leucine rich repeat, Ig-like and transmembrane domains 2; I-set domain containing | 0.645 |
| CDHR1 | LRIT1 | ENSP00000485478 | ENSP00000361177 | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity); Cadherin related | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing | 0.666 |
| CDHR1 | LRIT2 | ENSP00000485478 | ENSP00000438264 | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity); Cadherin related | Leucine rich repeat, Ig-like and transmembrane domains 2; I-set domain containing | 0.625 |
| HPCAL1 | C10orf99 | ENSP00000483786 | ENSP00000361199 | Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G- protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest | 0.424 |
| HPCAL1 | LRIT1 | ENSP00000483786 | ENSP00000361177 | Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing | 0.505 |
| HPCAL1 | LRIT2 | ENSP00000483786 | ENSP00000438264 | Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family | Leucine rich repeat, Ig-like and transmembrane domains 2; I-set domain containing | 0.571 |
| LPHN1 | LRIT1 | ENSP00000340688 | ENSP00000361177 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing | 0.688 |
| LPHN1 | LRIT2 | ENSP00000340688 | ENSP00000438264 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine rich repeat, Ig-like and transmembrane domains 2; I-set domain containing | 0.685 |
| LPHN1 | LRRC8B | ENSP00000340688 | ENSP00000332674 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition | 0.700 |
| LPHN2 | LRIT1 | ENSP00000322270 | ENSP00000361177 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing | 0.688 |
| LPHN2 | LRIT2 | ENSP00000322270 | ENSP00000438264 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine rich repeat, Ig-like and transmembrane domains 2; I-set domain containing | 0.685 |
| LPHN2 | LRRC8B | ENSP00000322270 | ENSP00000332674 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition | 0.700 |
| LPHN3 | LRIT1 | ENSP00000422533 | ENSP00000361177 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing | 0.688 |
| LPHN3 | LRIT2 | ENSP00000422533 | ENSP00000438264 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine rich repeat, Ig-like and transmembrane domains 2; I-set domain containing | 0.685 |
| LPHN3 | LRRC8B | ENSP00000422533 | ENSP00000332674 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition | 0.761 |
| LRIT1 | C10orf99 | ENSP00000361177 | ENSP00000361199 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G- protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest | 0.580 |
| LRIT1 | CDHR1 | ENSP00000361177 | ENSP00000485478 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity); Cadherin related | 0.666 |
