• Version:
  • 11.0 [archived version]
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MVK MVK OR4K13 OR4K13 STK38L STK38L ESF1 ESF1 DAPK2 DAPK2 CCDC91 CCDC91 GGA1 GGA1 PATE2 PATE2 GGA2 GGA2 ZBTB40 ZBTB40 LLPH LLPH
"CCDC91" - Coiled-coil domain-containing protein 91 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CCDC91Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes (441 aa)    
Predicted Functional Partners:
GGA1
ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (639 aa)
       
 
  0.929
ESF1
ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) (851 aa)
     
   
  0.675
GGA2
ADP-ribosylation factor-binding protein GGA2; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (613 aa)
       
 
  0.646
LLPH
Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission (129 aa)
           
  0.584
STK38L
Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells (464 aa)
     
   
  0.571
PATE2
Prostate and testis expressed 2; LY6/PLAUR domain containing (113 aa)
           
  0.570
OR4K13
Olfactory receptor 4K13; Odorant receptor; Olfactory receptors, family 4 (304 aa)
           
  0.543
DAPK2
Death-associated protein kinase 2; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in g [...] (370 aa)
       
      0.539
MVK
Mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway; Belongs to the GHMP kinase family. Mevalonate kinase subfamily (396 aa)
       
      0.536
ZBTB40
Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation; BTB domain containing (1239 aa)
           
  0.535
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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