node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C12orf43 | FAM169A | ENSP00000437803 | ENSP00000373808 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | Soluble lamin-associated protein of 75 kDa; Family with sequence similarity 169 member A; Belongs to the FAM169 family | 0.491 |
C12orf43 | FBXO2 | ENSP00000437803 | ENSP00000346240 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotrans [...] | 0.445 |
C12orf43 | LANCL3 | ENSP00000437803 | ENSP00000367882 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | LanC-like protein 3; LanC like 3 | 0.599 |
C12orf43 | MRAS | ENSP00000437803 | ENSP00000289104 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | Ras-related protein M-Ras; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway; Belongs to the small GTPase superfamily. Ras family | 0.516 |
C12orf43 | OAZ1 | ENSP00000437803 | ENSP00000473381 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular u [...] | 0.498 |
C12orf43 | TMEM130 | ENSP00000437803 | ENSP00000413163 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | Transmembrane protein 130 | 0.497 |
C12orf43 | TSSK6 | ENSP00000437803 | ENSP00000466477 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity) | 0.400 |
C12orf43 | UBE2QL1 | ENSP00000437803 | ENSP00000382713 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | Ubiquitin-conjugating enzyme E2Q-like protein 1; Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7; Belongs to the ubiquitin-conjugating enzyme family | 0.447 |
C12orf43 | ZKSCAN8 | ENSP00000437803 | ENSP00000332750 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | Zinc finger protein with KRAB and SCAN domains 8; May be involved in transcriptional regulation; SCAN domain containing | 0.517 |
FAM169A | C12orf43 | ENSP00000373808 | ENSP00000437803 | Soluble lamin-associated protein of 75 kDa; Family with sequence similarity 169 member A; Belongs to the FAM169 family | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | 0.491 |
FBXO2 | C12orf43 | ENSP00000346240 | ENSP00000437803 | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotrans [...] | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | 0.445 |
FBXO2 | LANCL3 | ENSP00000346240 | ENSP00000367882 | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotrans [...] | LanC-like protein 3; LanC like 3 | 0.429 |
LANCL3 | C12orf43 | ENSP00000367882 | ENSP00000437803 | LanC-like protein 3; LanC like 3 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | 0.599 |
LANCL3 | FBXO2 | ENSP00000367882 | ENSP00000346240 | LanC-like protein 3; LanC like 3 | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotrans [...] | 0.429 |
LANCL3 | TMEM130 | ENSP00000367882 | ENSP00000413163 | LanC-like protein 3; LanC like 3 | Transmembrane protein 130 | 0.490 |
LANCL3 | UBE2QL1 | ENSP00000367882 | ENSP00000382713 | LanC-like protein 3; LanC like 3 | Ubiquitin-conjugating enzyme E2Q-like protein 1; Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7; Belongs to the ubiquitin-conjugating enzyme family | 0.468 |
MRAS | C12orf43 | ENSP00000289104 | ENSP00000437803 | Ras-related protein M-Ras; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway; Belongs to the small GTPase superfamily. Ras family | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | 0.516 |
OAZ1 | C12orf43 | ENSP00000473381 | ENSP00000437803 | Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular u [...] | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | 0.498 |
TMEM130 | C12orf43 | ENSP00000413163 | ENSP00000437803 | Transmembrane protein 130 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 | 0.497 |
TMEM130 | LANCL3 | ENSP00000413163 | ENSP00000367882 | Transmembrane protein 130 | LanC-like protein 3; LanC like 3 | 0.490 |