• Version:
  • 11.0 [archived version]
STRINGSTRING
TRIM28 TRIM28 EMID1 EMID1 RSPH10B RSPH10B ADAL ADAL ZNF611 ZNF611 SLFN11 SLFN11 RPP38 RPP38 KIAA2022 KIAA2022 RSPH10B2 RSPH10B2 NXPE3 NXPE3 ZDHHC15 ZDHHC15
"ZNF611" - Zinc finger protein 611 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF611Zinc finger protein 611; May be involved in transcriptional regulation; Zinc fingers C2H2-type (705 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.908
NXPE3
NXPE family member 3; Neurexophilin and PC-esterase domain family member 3 (559 aa)
           
  0.685
RSPH10B
Radial spoke head 10 homolog B (870 aa)
           
  0.670
RSPH10B2
Radial spoke head 10 homolog B2 (870 aa)
           
  0.643
ADAL
Adenosine deaminase-like protein; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity) (328 aa)
           
  0.582
RPP38
Ribonuclease P protein subunit p38; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus; Belongs to the eukaryotic ribosomal protein eL8 family (283 aa)
           
  0.525
EMID1
EMI domain containing 1 (443 aa)
           
  0.511
ZDHHC15
Palmitoyltransferase ZDHHC15; Palmitoyltransferase specific for GAP43 and DLG4/PSD95; Belongs to the DHHC palmitoyltransferase family (337 aa)
     
 
  0.501
KIAA2022
Neurite extension and migration factor; Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1) (1516 aa)
           
  0.450
SLFN11
Schlafen family member 11; Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon- usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear- may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacy [...] (901 aa)
           
  0.448
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]