• Version:
  • 11.0 [archived version]
STRINGSTRING
NRG4 NRG4 NACC1 NACC1 SCGB1D2 SCGB1D2 C16orf93 C16orf93 PRSS53 PRSS53 FAM53A FAM53A TTC9B TTC9B RTBDN RTBDN ERICH1 ERICH1
"C16orf93" - Coiled-coil domain-containing protein 189 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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C16orf93Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 (331 aa)    
Predicted Functional Partners:
FAM53A
Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle (398 aa)
           
  0.669
PRSS53
Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases (553 aa)
           
  0.623
SCGB1D2
Secretoglobin family 1D member 2; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones; Secretoglobins (90 aa)
       
      0.622
NRG4
Pro-neuregulin-4, membrane-bound isoform; Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity) (115 aa)
           
  0.619
NACC1
Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines; BEN domain containing (527 aa)
           
  0.530
RTBDN
Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport (261 aa)
           
  0.495
TTC9B
Tetratricopeptide repeat domain containing (239 aa)
           
  0.428
ERICH1
Glutamate-rich protein 1; Glutamate rich 1 (443 aa)
           
  0.420
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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