• Version:
  • 11.0 [archived version]
STRINGSTRING
RNF135 RNF135 KIF9 KIF9 CDKL1 CDKL1 TMEM218 TMEM218 CEP89 CEP89 SCLT1 SCLT1 TMEM67 TMEM67 TCTN2 TCTN2 TMEM237 TMEM237 B9D1 B9D1 TMEM107 TMEM107
"TMEM218" - Transmembrane protein 218 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TMEM218Transmembrane protein 218; May be involved in ciliary biogenesis or function (115 aa)    
Predicted Functional Partners:
CDKL1
Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 (358 aa)
           
  0.771
RNF135
E3 ubiquitin-protein ligase RNF135; Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production; Ring finger proteins (432 aa)
           
  0.667
TCTN2
Tectonic-2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity) (697 aa)
           
  0.597
B9D1
B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family (204 aa)
       
 
  0.580
TMEM107
Transmembrane protein 107; Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (146 aa)
           
  0.567
TMEM67
Meckelin; Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC) (995 aa)
           
  0.563
TMEM237
Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family (408 aa)
           
  0.555
KIF9
Kinesin-like protein KIF9; Kinesin family member 9; Kinesins (790 aa)
           
  0.551
CEP89
Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity (783 aa)
           
  0.549
SCLT1
Sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) (688 aa)
           
  0.539
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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