node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B9D1 | CEP89 | ENSP00000261499 | ENSP00000306105 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity | 0.930 |
B9D1 | SCLT1 | ENSP00000261499 | ENSP00000281142 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) | 0.925 |
B9D1 | TCTN2 | ENSP00000261499 | ENSP00000304941 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Tectonic-2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity) | 0.981 |
B9D1 | TMEM107 | ENSP00000261499 | ENSP00000314116 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Transmembrane protein 107; Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins | 0.875 |
B9D1 | TMEM218 | ENSP00000261499 | ENSP00000436596 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Transmembrane protein 218; May be involved in ciliary biogenesis or function | 0.580 |
B9D1 | TMEM237 | ENSP00000261499 | ENSP00000386264 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family | 0.741 |
B9D1 | TMEM67 | ENSP00000261499 | ENSP00000389998 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Meckelin; Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC) | 0.986 |
CDKL1 | CEP89 | ENSP00000379176 | ENSP00000306105 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity | 0.447 |
CDKL1 | SCLT1 | ENSP00000379176 | ENSP00000281142 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) | 0.448 |
CDKL1 | TCTN2 | ENSP00000379176 | ENSP00000304941 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Tectonic-2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity) | 0.490 |
CDKL1 | TMEM218 | ENSP00000379176 | ENSP00000436596 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Transmembrane protein 218; May be involved in ciliary biogenesis or function | 0.771 |
CEP89 | B9D1 | ENSP00000306105 | ENSP00000261499 | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | 0.930 |
CEP89 | CDKL1 | ENSP00000306105 | ENSP00000379176 | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.447 |
CEP89 | SCLT1 | ENSP00000306105 | ENSP00000281142 | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity | Sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) | 0.992 |
CEP89 | TCTN2 | ENSP00000306105 | ENSP00000304941 | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity | Tectonic-2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity) | 0.939 |
CEP89 | TMEM218 | ENSP00000306105 | ENSP00000436596 | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity | Transmembrane protein 218; May be involved in ciliary biogenesis or function | 0.549 |
CEP89 | TMEM67 | ENSP00000306105 | ENSP00000389998 | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity | Meckelin; Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC) | 0.948 |
KIF9 | RNF135 | ENSP00000333942 | ENSP00000328340 | Kinesin-like protein KIF9; Kinesin family member 9; Kinesins | E3 ubiquitin-protein ligase RNF135; Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production; Ring finger proteins | 0.405 |
KIF9 | TMEM218 | ENSP00000333942 | ENSP00000436596 | Kinesin-like protein KIF9; Kinesin family member 9; Kinesins | Transmembrane protein 218; May be involved in ciliary biogenesis or function | 0.551 |
RNF135 | KIF9 | ENSP00000328340 | ENSP00000333942 | E3 ubiquitin-protein ligase RNF135; Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production; Ring finger proteins | Kinesin-like protein KIF9; Kinesin family member 9; Kinesins | 0.405 |