| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALKBH8 | CWF19L2 | ENSP00000397673 | ENSP00000282251 | Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in t [...] | CWF19-like protein 2; CWF19 like 2, cell cycle control; Belongs to the CWF19 family | 0.440 |
| ALKBH8 | KBTBD3 | ENSP00000397673 | ENSP00000436262 | Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in t [...] | Kelch repeat and BTB domain containing 3 | 0.474 |
| CHMP2A | EGFL7 | ENSP00000469240 | ENSP00000360764 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis | 0.451 |
| CHMP2A | KBTBD3 | ENSP00000469240 | ENSP00000436262 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Kelch repeat and BTB domain containing 3 | 0.751 |
| CHMP2A | ZC3H12C | ENSP00000469240 | ENSP00000278590 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Probable ribonuclease ZC3H12C; May function as RNase and regulate the levels of target RNA species; Belongs to the ZC3H12 family | 0.661 |
| CPA4 | KBTBD3 | ENSP00000222482 | ENSP00000436262 | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family | Kelch repeat and BTB domain containing 3 | 0.410 |
| CWF19L2 | ALKBH8 | ENSP00000282251 | ENSP00000397673 | CWF19-like protein 2; CWF19 like 2, cell cycle control; Belongs to the CWF19 family | Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in t [...] | 0.440 |
| CWF19L2 | GUCY1A2 | ENSP00000282251 | ENSP00000282249 | CWF19-like protein 2; CWF19 like 2, cell cycle control; Belongs to the CWF19 family | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.452 |
| CWF19L2 | KBTBD3 | ENSP00000282251 | ENSP00000436262 | CWF19-like protein 2; CWF19 like 2, cell cycle control; Belongs to the CWF19 family | Kelch repeat and BTB domain containing 3 | 0.680 |
| CWF19L2 | MSANTD4 | ENSP00000282251 | ENSP00000304713 | CWF19-like protein 2; CWF19 like 2, cell cycle control; Belongs to the CWF19 family | Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils | 0.558 |
| EGFL7 | CHMP2A | ENSP00000360764 | ENSP00000469240 | Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.451 |
| EGFL7 | KBTBD3 | ENSP00000360764 | ENSP00000436262 | Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis | Kelch repeat and BTB domain containing 3 | 0.593 |
| GUCY1A2 | CWF19L2 | ENSP00000282249 | ENSP00000282251 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | CWF19-like protein 2; CWF19 like 2, cell cycle control; Belongs to the CWF19 family | 0.452 |
| GUCY1A2 | KBTBD3 | ENSP00000282249 | ENSP00000436262 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | Kelch repeat and BTB domain containing 3 | 0.526 |
| KBTBD3 | ALKBH8 | ENSP00000436262 | ENSP00000397673 | Kelch repeat and BTB domain containing 3 | Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in t [...] | 0.474 |
| KBTBD3 | CHMP2A | ENSP00000436262 | ENSP00000469240 | Kelch repeat and BTB domain containing 3 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.751 |
| KBTBD3 | CPA4 | ENSP00000436262 | ENSP00000222482 | Kelch repeat and BTB domain containing 3 | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family | 0.410 |
| KBTBD3 | CWF19L2 | ENSP00000436262 | ENSP00000282251 | Kelch repeat and BTB domain containing 3 | CWF19-like protein 2; CWF19 like 2, cell cycle control; Belongs to the CWF19 family | 0.680 |
| KBTBD3 | EGFL7 | ENSP00000436262 | ENSP00000360764 | Kelch repeat and BTB domain containing 3 | Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis | 0.593 |
| KBTBD3 | GUCY1A2 | ENSP00000436262 | ENSP00000282249 | Kelch repeat and BTB domain containing 3 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.526 |
