| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARFGEF1 | TP53I11 | ENSP00000262215 | ENSP00000436152 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and [...] | Tumor protein p53 inducible protein 11 | 0.628 |
| EFCAB10 | SNTN | ENSP00000418678 | ENSP00000341442 | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10 | Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules | 0.643 |
| EFCAB10 | TP53I11 | ENSP00000418678 | ENSP00000436152 | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10 | Tumor protein p53 inducible protein 11 | 0.492 |
| ENDOD1 | TP53I11 | ENSP00000278505 | ENSP00000436152 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | Tumor protein p53 inducible protein 11 | 0.522 |
| ENSG00000278848 | TP53I11 | ENSP00000485635 | ENSP00000436152 | TP53-target gene 3 protein; May play a significant role in p53/TP53-mediating signaling pathway | Tumor protein p53 inducible protein 11 | 0.473 |
| PHLDA2 | TP53I11 | ENSP00000319231 | ENSP00000436152 | Pleckstrin homology-like domain family A member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity); Belongs to the PHLDA2 family | Tumor protein p53 inducible protein 11 | 0.494 |
| SNTN | EFCAB10 | ENSP00000341442 | ENSP00000418678 | Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10 | 0.643 |
| SNTN | TP53I11 | ENSP00000341442 | ENSP00000436152 | Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules | Tumor protein p53 inducible protein 11 | 0.489 |
| TP53 | TP53I11 | ENSP00000269305 | ENSP00000436152 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | Tumor protein p53 inducible protein 11 | 0.528 |
| TP53 | TP53INP2 | ENSP00000269305 | ENSP00000363943 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | Tumor protein p53-inducible nuclear protein 2; Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA | 0.541 |
| TP53I11 | ARFGEF1 | ENSP00000436152 | ENSP00000262215 | Tumor protein p53 inducible protein 11 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and [...] | 0.628 |
| TP53I11 | EFCAB10 | ENSP00000436152 | ENSP00000418678 | Tumor protein p53 inducible protein 11 | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10 | 0.492 |
| TP53I11 | ENDOD1 | ENSP00000436152 | ENSP00000278505 | Tumor protein p53 inducible protein 11 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | 0.522 |
| TP53I11 | ENSG00000278848 | ENSP00000436152 | ENSP00000485635 | Tumor protein p53 inducible protein 11 | TP53-target gene 3 protein; May play a significant role in p53/TP53-mediating signaling pathway | 0.473 |
| TP53I11 | PHLDA2 | ENSP00000436152 | ENSP00000319231 | Tumor protein p53 inducible protein 11 | Pleckstrin homology-like domain family A member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity); Belongs to the PHLDA2 family | 0.494 |
| TP53I11 | SNTN | ENSP00000436152 | ENSP00000341442 | Tumor protein p53 inducible protein 11 | Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules | 0.489 |
| TP53I11 | TP53 | ENSP00000436152 | ENSP00000269305 | Tumor protein p53 inducible protein 11 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.528 |
| TP53I11 | TP53INP2 | ENSP00000436152 | ENSP00000363943 | Tumor protein p53 inducible protein 11 | Tumor protein p53-inducible nuclear protein 2; Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA | 0.575 |
| TP53I11 | TXNL1 | ENSP00000436152 | ENSP00000217515 | Tumor protein p53 inducible protein 11 | Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV | 0.649 |
| TP53I11 | WBP2 | ENSP00000436152 | ENSP00000467579 | Tumor protein p53 inducible protein 11 | WW domain-binding protein 2; Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1- responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity); GRAM domain containing | 0.538 |
