| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C17orf97 | CRACR2B | ENSP00000353245 | ENSP00000435299 | Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | 0.584 |
| CDH23 | CRACR2B | ENSP00000381768 | ENSP00000435299 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | 0.504 |
| CDH23 | PADI1 | ENSP00000381768 | ENSP00000364620 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | 0.424 |
| CDH8 | CRACR2B | ENSP00000462701 | ENSP00000435299 | Cadherin-8; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | 0.559 |
| CHID1 | CRACR2B | ENSP00000398722 | ENSP00000435299 | Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro); Belongs to the glycosyl hydrolase 18 family | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | 0.474 |
| CRACR2B | C17orf97 | ENSP00000435299 | ENSP00000353245 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation | 0.584 |
| CRACR2B | CDH23 | ENSP00000435299 | ENSP00000381768 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | 0.504 |
| CRACR2B | CDH8 | ENSP00000435299 | ENSP00000462701 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Cadherin-8; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.559 |
| CRACR2B | CHID1 | ENSP00000435299 | ENSP00000398722 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro); Belongs to the glycosyl hydrolase 18 family | 0.474 |
| CRACR2B | GNPTAB | ENSP00000435299 | ENSP00000299314 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment; EF-hand domain containing | 0.561 |
| CRACR2B | MAN1A2 | ENSP00000435299 | ENSP00000348959 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) | 0.689 |
| CRACR2B | PADI1 | ENSP00000435299 | ENSP00000364620 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | 0.565 |
| CRACR2B | PCDHAC1 | ENSP00000435299 | ENSP00000253807 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.537 |
| CRACR2B | PRDM15 | ENSP00000435299 | ENSP00000269844 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | PR domain zinc finger protein 15; May be involved in transcriptional regulation; PR/SET domain family | 0.497 |
| CRACR2B | S100A3 | ENSP00000435299 | ENSP00000357702 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation; S100 calcium binding proteins | 0.541 |
| GNPTAB | CRACR2B | ENSP00000299314 | ENSP00000435299 | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment; EF-hand domain containing | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | 0.561 |
| MAN1A2 | CRACR2B | ENSP00000348959 | ENSP00000435299 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | 0.689 |
| MAN1A2 | PADI1 | ENSP00000348959 | ENSP00000364620 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | 0.400 |
| MAN1A2 | PCDHAC1 | ENSP00000348959 | ENSP00000253807 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.441 |
| PADI1 | CDH23 | ENSP00000364620 | ENSP00000381768 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | 0.424 |
