node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FBN1 | PXDN | ENSP00000325527 | ENSP00000252804 | Fibrillin-1; Fibrillin-1- Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus w [...] | Peroxidasin homolog; Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation; I-set domain containing | 0.439 |
FBN1 | TSKU | ENSP00000325527 | ENSP00000434847 | Fibrillin-1; Fibrillin-1- Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus w [...] | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.591 |
HSPA13 | TSKU | ENSP00000285667 | ENSP00000434847 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.601 |
LPHN1 | LRRC20 | ENSP00000340688 | ENSP00000348043 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 | 0.683 |
LPHN1 | TSKU | ENSP00000340688 | ENSP00000434847 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.685 |
LPHN2 | LRRC20 | ENSP00000322270 | ENSP00000348043 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 | 0.683 |
LPHN2 | TSKU | ENSP00000322270 | ENSP00000434847 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.685 |
LPHN3 | LRRC20 | ENSP00000422533 | ENSP00000348043 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 | 0.683 |
LPHN3 | TSKU | ENSP00000422533 | ENSP00000434847 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.685 |
LRRC20 | LPHN1 | ENSP00000348043 | ENSP00000340688 | Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.683 |
LRRC20 | LPHN2 | ENSP00000348043 | ENSP00000322270 | Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.683 |
LRRC20 | LPHN3 | ENSP00000348043 | ENSP00000422533 | Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.683 |
LRRC20 | TSKU | ENSP00000348043 | ENSP00000434847 | Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.583 |
PMCH | TSKU | ENSP00000332225 | ENSP00000434847 | Pro-MCH; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation; Belongs to the melanin-concentrating hormone family | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.643 |
PXDN | FBN1 | ENSP00000252804 | ENSP00000325527 | Peroxidasin homolog; Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation; I-set domain containing | Fibrillin-1; Fibrillin-1- Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus w [...] | 0.439 |
PXDN | TSKU | ENSP00000252804 | ENSP00000434847 | Peroxidasin homolog; Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation; I-set domain containing | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.587 |
TES | TSKU | ENSP00000350937 | ENSP00000434847 | Testin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth; LIM domain containing | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.844 |
TSKS | TSKU | ENSP00000246801 | ENSP00000434847 | Testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development; Protein phosphatase 1 regulatory subunits | Tsukushin; Tsukushi, small leucine rich proteoglycan | 0.573 |
TSKU | FBN1 | ENSP00000434847 | ENSP00000325527 | Tsukushin; Tsukushi, small leucine rich proteoglycan | Fibrillin-1; Fibrillin-1- Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus w [...] | 0.591 |
TSKU | HSPA13 | ENSP00000434847 | ENSP00000285667 | Tsukushin; Tsukushi, small leucine rich proteoglycan | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | 0.601 |