• Version:
  • 11.0 [archived version]
STRINGSTRING
ARHGEF39 ARHGEF39 HOGA1 HOGA1 MCU MCU ZNF346 ZNF346 TMEM126B TMEM126B CCDC90B CCDC90B TMX1 TMX1 NIPAL2 NIPAL2 TRMT1L TRMT1L WDR74 WDR74 MRPL53 MRPL53
"CCDC90B" - Coiled-coil domain-containing protein 90B, mitochondrial in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CCDC90BCoiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B (254 aa)    
Predicted Functional Partners:
TRMT1L
TRMT1-like protein; May play a role in motor coordination and exploratory behavior; tRNA methyltransferases (733 aa)
     
   
  0.765
MRPL53
Mitochondrial ribosomal protein L53 (112 aa)
           
  0.712
NIPAL2
NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family (368 aa)
           
  0.675
TMX1
Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions; Protein disulfide isomerases (280 aa)
     
   
  0.663
ZNF346
Zinc finger protein 346; Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins (294 aa)
     
   
  0.653
WDR74
WD repeat-containing protein 74; WD repeat domain containing (385 aa)
           
  0.625
HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline (327 aa)
           
  0.615
MCU
Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down- regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buff [...] (351 aa)
           
  0.589
ARHGEF39
Rho guanine nucleotide exchange factor 39; Promotes cell proliferation (335 aa)
           
  0.586
TMEM126B
Complex I assembly factor TMEM126B, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (230 aa)
     
        0.586
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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