node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF39 | CCDC90B | ENSP00000367638 | ENSP00000434724 | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | 0.586 |
CCDC90B | ARHGEF39 | ENSP00000434724 | ENSP00000367638 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation | 0.586 |
CCDC90B | HOGA1 | ENSP00000434724 | ENSP00000359680 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline | 0.615 |
CCDC90B | MCU | ENSP00000434724 | ENSP00000362144 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down- regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buff [...] | 0.589 |
CCDC90B | MRPL53 | ENSP00000434724 | ENSP00000258105 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | Mitochondrial ribosomal protein L53 | 0.712 |
CCDC90B | NIPAL2 | ENSP00000434724 | ENSP00000339256 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family | 0.675 |
CCDC90B | TMEM126B | ENSP00000434724 | ENSP00000351737 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | Complex I assembly factor TMEM126B, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I | 0.586 |
CCDC90B | TMX1 | ENSP00000434724 | ENSP00000393316 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions; Protein disulfide isomerases | 0.663 |
CCDC90B | TRMT1L | ENSP00000434724 | ENSP00000356476 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | TRMT1-like protein; May play a role in motor coordination and exploratory behavior; tRNA methyltransferases | 0.765 |
CCDC90B | WDR74 | ENSP00000434724 | ENSP00000432119 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | WD repeat-containing protein 74; WD repeat domain containing | 0.625 |
CCDC90B | ZNF346 | ENSP00000434724 | ENSP00000350869 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | Zinc finger protein 346; Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins | 0.653 |
HOGA1 | CCDC90B | ENSP00000359680 | ENSP00000434724 | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | 0.615 |
MCU | CCDC90B | ENSP00000362144 | ENSP00000434724 | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down- regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buff [...] | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | 0.589 |
MRPL53 | CCDC90B | ENSP00000258105 | ENSP00000434724 | Mitochondrial ribosomal protein L53 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | 0.712 |
MRPL53 | NIPAL2 | ENSP00000258105 | ENSP00000339256 | Mitochondrial ribosomal protein L53 | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family | 0.740 |
MRPL53 | WDR74 | ENSP00000258105 | ENSP00000432119 | Mitochondrial ribosomal protein L53 | WD repeat-containing protein 74; WD repeat domain containing | 0.730 |
NIPAL2 | CCDC90B | ENSP00000339256 | ENSP00000434724 | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | 0.675 |
NIPAL2 | MRPL53 | ENSP00000339256 | ENSP00000258105 | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family | Mitochondrial ribosomal protein L53 | 0.740 |
NIPAL2 | WDR74 | ENSP00000339256 | ENSP00000432119 | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family | WD repeat-containing protein 74; WD repeat domain containing | 0.653 |
TMEM126B | CCDC90B | ENSP00000351737 | ENSP00000434724 | Complex I assembly factor TMEM126B, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B | 0.586 |