• Version:
  • 11.0 [archived version]
STRINGSTRING
ANKDD1A ANKDD1A KANK1 KANK1 PCDHA8 PCDHA8 SH3BP5L SH3BP5L SPATA45 SPATA45 OR6K3 OR6K3 POTEH POTEH TCTEX1D2 TCTEX1D2 LENEP LENEP C1orf141 C1orf141
"PCDHA8" - Protocadherin alpha-8 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCDHA8Protocadherin alpha-8; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (950 aa)    
Predicted Functional Partners:
SPATA45
Spermatogenesis-associated protein 45; Spermatogenesis associated 45; Belongs to the SPATA45 family (98 aa)
           
  0.534
OR6K3
Olfactory receptor 6K3; Odorant receptor; Olfactory receptors, family 6 (315 aa)
           
  0.513
ANKDD1A
Ankyrin repeat and death domain containing 1A (522 aa)
       
 
  0.479
SH3BP5L
SH3 binding domain protein 5 like (393 aa)
           
  0.446
POTEH
POTE ankyrin domain family member H (545 aa)
           
  0.443
LENEP
Lens epithelial cell protein LEP503; May play a role in lens epithelial cell differentiation (61 aa)
           
  0.442
KANK1
KN motif and ankyrin repeat domain-containing protein 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronecti [...] (1352 aa)
       
 
  0.426
C1orf141
Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141 (400 aa)
           
  0.424
TCTEX1D2
Tctex1 domain-containing protein 2; Required for proper retrograde ciliary transport; Belongs to the dynein light chain Tctex-type family (142 aa)
           
  0.410
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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