| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C6orf141 | CDC42SE2 | ENSP00000434602 | ENSP00000427421 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages; Belongs to the CDC42SE/SPEC family | 0.424 |
| C6orf141 | ESYT3 | ENSP00000434602 | ENSP00000374218 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | Extended synaptotagmin-3; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Extended synaptotagmins | 0.429 |
| C6orf141 | FAM46A | ENSP00000434602 | ENSP00000318298 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | Putative nucleotidyltransferase FAM46A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase; Belongs to the FAM46 family | 0.422 |
| C6orf141 | FERD3L | ENSP00000434602 | ENSP00000275461 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity); Basic helix-loop-helix proteins | 0.473 |
| C6orf141 | NUDT6 | ENSP00000434602 | ENSP00000306070 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | Nucleoside diphosphate-linked moiety X motif 6; May contribute to the regulation of cell proliferation; Belongs to the Nudix hydrolase family | 0.422 |
| C6orf141 | PCDHGC4 | ENSP00000434602 | ENSP00000306918 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | Protocadherin gamma-C4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.540 |
| C6orf141 | PDCL3 | ENSP00000434602 | ENSP00000264254 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | 0.522 |
| C6orf141 | RPL11 | ENSP00000434602 | ENSP00000363676 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] | 0.406 |
| C6orf141 | SMAGP | ENSP00000434602 | ENSP00000475068 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | Small cell adhesion glycoprotein; May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation | 0.567 |
| C6orf141 | SYNE3 | ENSP00000434602 | ENSP00000334308 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | Nesprin-3; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is re [...] | 0.525 |
| CDC42SE2 | C6orf141 | ENSP00000427421 | ENSP00000434602 | CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages; Belongs to the CDC42SE/SPEC family | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | 0.424 |
| CDC42SE2 | SMAGP | ENSP00000427421 | ENSP00000475068 | CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages; Belongs to the CDC42SE/SPEC family | Small cell adhesion glycoprotein; May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation | 0.431 |
| ESYT3 | C6orf141 | ENSP00000374218 | ENSP00000434602 | Extended synaptotagmin-3; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Extended synaptotagmins | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | 0.429 |
| FAM46A | C6orf141 | ENSP00000318298 | ENSP00000434602 | Putative nucleotidyltransferase FAM46A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase; Belongs to the FAM46 family | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | 0.422 |
| FAM46A | SMAGP | ENSP00000318298 | ENSP00000475068 | Putative nucleotidyltransferase FAM46A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase; Belongs to the FAM46 family | Small cell adhesion glycoprotein; May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation | 0.450 |
| FERD3L | C6orf141 | ENSP00000275461 | ENSP00000434602 | Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity); Basic helix-loop-helix proteins | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | 0.473 |
| NUDT6 | C6orf141 | ENSP00000306070 | ENSP00000434602 | Nucleoside diphosphate-linked moiety X motif 6; May contribute to the regulation of cell proliferation; Belongs to the Nudix hydrolase family | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | 0.422 |
| NUDT6 | SMAGP | ENSP00000306070 | ENSP00000475068 | Nucleoside diphosphate-linked moiety X motif 6; May contribute to the regulation of cell proliferation; Belongs to the Nudix hydrolase family | Small cell adhesion glycoprotein; May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation | 0.421 |
| PCDHGC4 | C6orf141 | ENSP00000306918 | ENSP00000434602 | Protocadherin gamma-C4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | 0.540 |
| PDCL3 | C6orf141 | ENSP00000264254 | ENSP00000434602 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 | 0.522 |
