node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATAD3C | C8orf44 | ENSP00000368062 | ENSP00000428002 | ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.585 |
ATAD3C | CYB5RL | ENSP00000368062 | ENSP00000434343 | ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | 0.635 |
ATAD3C | ZNF714 | ENSP00000368062 | ENSP00000478345 | ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Zinc finger protein 714; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.590 |
C8orf44 | ATAD3C | ENSP00000428002 | ENSP00000368062 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | 0.585 |
C8orf44 | CYB5RL | ENSP00000428002 | ENSP00000434343 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | 0.646 |
C8orf44 | ZNF714 | ENSP00000428002 | ENSP00000478345 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | Zinc finger protein 714; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.658 |
CYB5A | CYB5RL | ENSP00000341625 | ENSP00000434343 | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | 0.840 |
CYB5A | FDXR | ENSP00000341625 | ENSP00000416515 | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | NADPH-adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver; Belongs to the ferredoxin--NADP reductase type 1 family | 0.618 |
CYB5A | POR | ENSP00000341625 | ENSP00000419970 | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; Belongs to the NADPH--cytochrome P450 reductase family | 0.964 |
CYB5RL | ATAD3C | ENSP00000434343 | ENSP00000368062 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | 0.635 |
CYB5RL | C8orf44 | ENSP00000434343 | ENSP00000428002 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.646 |
CYB5RL | CYB5A | ENSP00000434343 | ENSP00000341625 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | 0.840 |
CYB5RL | FDXR | ENSP00000434343 | ENSP00000416515 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | NADPH-adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver; Belongs to the ferredoxin--NADP reductase type 1 family | 0.620 |
CYB5RL | HBB | ENSP00000434343 | ENSP00000333994 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family | 0.905 |
CYB5RL | MOCOS | ENSP00000434343 | ENSP00000261326 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily | 0.537 |
CYB5RL | NANS | ENSP00000434343 | ENSP00000210444 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively | 0.513 |
CYB5RL | NFS1 | ENSP00000434343 | ENSP00000363205 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor | 0.535 |
CYB5RL | POR | ENSP00000434343 | ENSP00000419970 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; Belongs to the NADPH--cytochrome P450 reductase family | 0.763 |
CYB5RL | ZNF714 | ENSP00000434343 | ENSP00000478345 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Zinc finger protein 714; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.659 |
FDXR | CYB5A | ENSP00000416515 | ENSP00000341625 | NADPH-adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver; Belongs to the ferredoxin--NADP reductase type 1 family | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | 0.618 |