| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BTBD7 | C9orf156 | ENSP00000335615 | ENSP00000364260 | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing | tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity) | 0.412 |
| BTBD7 | FAM118B | ENSP00000335615 | ENSP00000433343 | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | 0.510 |
| C11orf95 | FAM118B | ENSP00000482180 | ENSP00000433343 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | 0.643 |
| C11orf95 | MAMLD1 | ENSP00000482180 | ENSP00000414517 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family | 0.497 |
| C9orf156 | BTBD7 | ENSP00000364260 | ENSP00000335615 | tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity) | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing | 0.412 |
| C9orf156 | FAM118B | ENSP00000364260 | ENSP00000433343 | tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity) | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | 0.586 |
| C9orf156 | NIPSNAP1 | ENSP00000364260 | ENSP00000216121 | tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity) | Nipsnap homolog 1 | 0.400 |
| CIB3 | FAM118B | ENSP00000269878 | ENSP00000433343 | Calcium and integrin binding family member 3; EF-hand domain containing | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | 0.522 |
| CIB3 | PIGV | ENSP00000269878 | ENSP00000363260 | Calcium and integrin binding family member 3; EF-hand domain containing | GPI mannosyltransferase 2; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly; Dolichyl D-mannosyl phosphate dependent mannosyltransferases | 0.553 |
| COL24A1 | FAM118B | ENSP00000359603 | ENSP00000433343 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | 0.508 |
| FAM118B | BTBD7 | ENSP00000433343 | ENSP00000335615 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing | 0.510 |
| FAM118B | C11orf95 | ENSP00000433343 | ENSP00000482180 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | 0.643 |
| FAM118B | C9orf156 | ENSP00000433343 | ENSP00000364260 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity) | 0.586 |
| FAM118B | CIB3 | ENSP00000433343 | ENSP00000269878 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Calcium and integrin binding family member 3; EF-hand domain containing | 0.522 |
| FAM118B | COL24A1 | ENSP00000433343 | ENSP00000359603 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | 0.508 |
| FAM118B | FAM188B | ENSP00000433343 | ENSP00000265299 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins | 0.522 |
| FAM118B | MAMLD1 | ENSP00000433343 | ENSP00000414517 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family | 0.538 |
| FAM118B | NIPSNAP1 | ENSP00000433343 | ENSP00000216121 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Nipsnap homolog 1 | 0.500 |
| FAM118B | PIGV | ENSP00000433343 | ENSP00000363260 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | GPI mannosyltransferase 2; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly; Dolichyl D-mannosyl phosphate dependent mannosyltransferases | 0.506 |
| FAM118B | TINF2 | ENSP00000433343 | ENSP00000267415 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | TERF1-interacting nuclear factor 2; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix | 0.501 |
