| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACRV1 | ACVR1 | ENSP00000432816 | ENSP00000263640 | Acrosomal vesicle protein 1 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity) | 0.741 |
| ACRV1 | LIPN | ENSP00000432816 | ENSP00000383923 | Acrosomal vesicle protein 1 | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases | 0.789 |
| ACRV1 | LRP5 | ENSP00000432816 | ENSP00000294304 | Acrosomal vesicle protein 1 | Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] | 0.641 |
| ACRV1 | MBD3L2 | ENSP00000432816 | ENSP00000370800 | Acrosomal vesicle protein 1 | methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family | 0.701 |
| ACRV1 | SP6 | ENSP00000432816 | ENSP00000438209 | Acrosomal vesicle protein 1 | Transcription factor Sp6; Promotes cell proliferation; Sp transcription factors | 0.737 |
| ACRV1 | SP8 | ENSP00000432816 | ENSP00000408792 | Acrosomal vesicle protein 1 | Transcription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity); Sp transcription factors | 0.670 |
| ACRV1 | SP9 | ENSP00000432816 | ENSP00000378418 | Acrosomal vesicle protein 1 | Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity); Sp transcription factors | 0.860 |
| ACRV1 | SPACA1 | ENSP00000432816 | ENSP00000237201 | Acrosomal vesicle protein 1 | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | 0.827 |
| ACRV1 | SPACA3 | ENSP00000432816 | ENSP00000269053 | Acrosomal vesicle protein 1 | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro; Lysozymes, c-type | 0.629 |
| ACRV1 | SPACA4 | ENSP00000432816 | ENSP00000312774 | Acrosomal vesicle protein 1 | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing | 0.717 |
| ACVR1 | ACRV1 | ENSP00000263640 | ENSP00000432816 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity) | Acrosomal vesicle protein 1 | 0.741 |
| LIPN | ACRV1 | ENSP00000383923 | ENSP00000432816 | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases | Acrosomal vesicle protein 1 | 0.789 |
| LIPN | LRP5 | ENSP00000383923 | ENSP00000294304 | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases | Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] | 0.836 |
| LIPN | SP6 | ENSP00000383923 | ENSP00000438209 | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases | Transcription factor Sp6; Promotes cell proliferation; Sp transcription factors | 0.860 |
| LIPN | SP8 | ENSP00000383923 | ENSP00000408792 | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases | Transcription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity); Sp transcription factors | 0.441 |
| LIPN | SP9 | ENSP00000383923 | ENSP00000378418 | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases | Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity); Sp transcription factors | 0.789 |
| LRP5 | ACRV1 | ENSP00000294304 | ENSP00000432816 | Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] | Acrosomal vesicle protein 1 | 0.641 |
| LRP5 | LIPN | ENSP00000294304 | ENSP00000383923 | Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases | 0.836 |
| LRP5 | SP6 | ENSP00000294304 | ENSP00000438209 | Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] | Transcription factor Sp6; Promotes cell proliferation; Sp transcription factors | 0.688 |
| LRP5 | SP9 | ENSP00000294304 | ENSP00000378418 | Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] | Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity); Sp transcription factors | 0.559 |
