node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC8 | WDR26 | ENSP00000420333 | ENSP00000408108 | Armadillo repeat containing 8 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.961 |
ARMC8 | YPEL4 | ENSP00000420333 | ENSP00000432648 | Armadillo repeat containing 8 | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.619 |
C1QL2 | FNDC5 | ENSP00000272520 | ENSP00000362570 | Complement C1q-like protein 2; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | 0.586 |
C1QL2 | YPEL4 | ENSP00000272520 | ENSP00000432648 | Complement C1q-like protein 2; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.736 |
C1QL3 | FNDC5 | ENSP00000298943 | ENSP00000362570 | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity); C1q and TNF related | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | 0.568 |
C1QL3 | YPEL4 | ENSP00000298943 | ENSP00000432648 | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity); C1q and TNF related | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.694 |
C1QL4 | FNDC5 | ENSP00000335285 | ENSP00000362570 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | 0.579 |
C1QL4 | YPEL4 | ENSP00000335285 | ENSP00000432648 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.750 |
FNDC5 | C1QL2 | ENSP00000362570 | ENSP00000272520 | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | Complement C1q-like protein 2; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related | 0.586 |
FNDC5 | C1QL3 | ENSP00000362570 | ENSP00000298943 | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity); C1q and TNF related | 0.568 |
FNDC5 | C1QL4 | ENSP00000362570 | ENSP00000335285 | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | 0.579 |
FNDC5 | YPEL4 | ENSP00000362570 | ENSP00000432648 | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.611 |
OR2T6 | YPEL4 | ENSP00000347965 | ENSP00000432648 | Olfactory receptor 2T6; Odorant receptor; Olfactory receptors, family 2 | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.645 |
OR6K2 | YPEL4 | ENSP00000352626 | ENSP00000432648 | Olfactory receptor 6K2; Odorant receptor; Olfactory receptors, family 6 | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.670 |
OR9G4 | YPEL4 | ENSP00000307515 | ENSP00000432648 | Olfactory receptor 9G4; Odorant receptor; Olfactory receptors, family 9 | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.630 |
PPP1R10 | YPEL4 | ENSP00000365694 | ENSP00000432648 | Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.637 |
WDR26 | ARMC8 | ENSP00000408108 | ENSP00000420333 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | Armadillo repeat containing 8 | 0.961 |
WDR26 | YPEL4 | ENSP00000408108 | ENSP00000432648 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.827 |
YPEL4 | ARMC8 | ENSP00000432648 | ENSP00000420333 | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | Armadillo repeat containing 8 | 0.619 |
YPEL4 | C1QL2 | ENSP00000432648 | ENSP00000272520 | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | Complement C1q-like protein 2; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related | 0.736 |