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  • 11.0 [archived version]
STRINGSTRING
OR2T6 OR2T6 OR6K2 OR6K2 PPP1R10 PPP1R10 C1QL3 C1QL3 YPEL4 YPEL4 FNDC5 FNDC5 OR9G4 OR9G4 C1QL4 C1QL4 C1QL2 C1QL2 ARMC8 ARMC8 WDR26 WDR26
"YPEL4" - Protein yippee-like 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
YPEL4Protein yippee-like 4; Yippee like family; Belongs to the yippee family (127 aa)    
Predicted Functional Partners:
WDR26
WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] (661 aa)
     
 
  0.827
C1QL4
Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related (238 aa)
           
  0.750
C1QL2
Complement C1q-like protein 2; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related (287 aa)
     
   
  0.736
C1QL3
Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity); C1q and TNF related (255 aa)
     
   
  0.694
OR6K2
Olfactory receptor 6K2; Odorant receptor; Olfactory receptors, family 6 (324 aa)
           
  0.670
OR2T6
Olfactory receptor 2T6; Odorant receptor; Olfactory receptors, family 2 (308 aa)
           
  0.645
PPP1R10
Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] (940 aa)
           
  0.637
OR9G4
Olfactory receptor 9G4; Odorant receptor; Olfactory receptors, family 9 (327 aa)
           
  0.630
ARMC8
Armadillo repeat containing 8 (659 aa)
     
 
  0.619
FNDC5
Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing (212 aa)
     
   
  0.611
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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