• Version:
  • 11.0 [archived version]
STRINGSTRING
LIME1 LIME1 ZNF229 ZNF229 OR4F6 OR4F6 AP1S1 AP1S1 SPATC1L SPATC1L EBLN2 EBLN2 TUSC2 TUSC2 TCEB3C TCEB3C ZNF311 ZNF311 KIAA2018 KIAA2018 GON4L GON4L
"EBLN2" - Endogenous Bornavirus-like nucleoprotein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
EBLN2Endogenous Bornavirus-like nucleoprotein 2; May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human (272 aa)    
Predicted Functional Partners:
TUSC2
Tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells; Belongs to the TUSC2 family (110 aa)
       
 
  0.710
OR4F6
Olfactory receptor 4F6; Odorant receptor; Olfactory receptors, family 4 (312 aa)
           
  0.670
ZNF229
Zinc finger protein 229; May be involved in transcriptional regulation; Zinc fingers C2H2-type (825 aa)
           
  0.642
AP1S1
AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (158 aa)
       
 
  0.607
ZNF311
Zinc finger protein 311; May be involved in transcriptional regulation; Zinc fingers C2H2-type (666 aa)
           
  0.556
SPATC1L
Speriolin-like protein; Spermatogenesis and centriole associated 1 like (340 aa)
           
  0.526
KIAA2018
Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial- mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties (2245 aa)
           
  0.520
TCEB3C
Elongin-A3; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (546 aa)
           
  0.516
GON4L
GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis; Myb/SANT domain containing (2241 aa)
           
  0.474
LIME1
Lck-interacting transmembrane adapter 1; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules (295 aa)
           
  0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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