| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C19orf57 | C19orf67 | ENSP00000254336 | ENSP00000449137 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57 | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family | 0.700 |
| C19orf57 | SAMD1 | ENSP00000254336 | ENSP00000431971 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57 | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.527 |
| C19orf67 | C19orf57 | ENSP00000449137 | ENSP00000254336 | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57 | 0.700 |
| C19orf67 | SAMD1 | ENSP00000449137 | ENSP00000431971 | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.581 |
| ELP3 | SAMD1 | ENSP00000256398 | ENSP00000431971 | Elongator complex protein 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin. May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a proc [...] | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.542 |
| EPC1 | EPC2 | ENSP00000263062 | ENSP00000258484 | Enhancer of polycomb homolog 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | Enhancer of polycomb homolog 2; May play a role in transcription or DNA repair | 0.617 |
| EPC1 | MSL1 | ENSP00000263062 | ENSP00000462945 | Enhancer of polycomb homolog 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together fo [...] | 0.902 |
| EPC1 | SAMD1 | ENSP00000263062 | ENSP00000431971 | Enhancer of polycomb homolog 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.528 |
| EPC2 | EPC1 | ENSP00000258484 | ENSP00000263062 | Enhancer of polycomb homolog 2; May play a role in transcription or DNA repair | Enhancer of polycomb homolog 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.617 |
| EPC2 | MSL1 | ENSP00000258484 | ENSP00000462945 | Enhancer of polycomb homolog 2; May play a role in transcription or DNA repair | Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together fo [...] | 0.550 |
| EPC2 | SAMD1 | ENSP00000258484 | ENSP00000431971 | Enhancer of polycomb homolog 2; May play a role in transcription or DNA repair | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.528 |
| L3MBTL3 | PRMT2 | ENSP00000431962 | ENSP00000380759 | Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity); MBT domain containing | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation; Belongs to the class [...] | 0.586 |
| L3MBTL3 | SAMD1 | ENSP00000431962 | ENSP00000431971 | Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity); MBT domain containing | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.834 |
| MSL1 | EPC1 | ENSP00000462945 | ENSP00000263062 | Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together fo [...] | Enhancer of polycomb homolog 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.902 |
| MSL1 | EPC2 | ENSP00000462945 | ENSP00000258484 | Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together fo [...] | Enhancer of polycomb homolog 2; May play a role in transcription or DNA repair | 0.550 |
| MSL1 | SAMD1 | ENSP00000462945 | ENSP00000431971 | Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together fo [...] | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.758 |
| PRMT2 | L3MBTL3 | ENSP00000380759 | ENSP00000431962 | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation; Belongs to the class [...] | Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity); MBT domain containing | 0.586 |
| PRMT2 | SAMD1 | ENSP00000380759 | ENSP00000431971 | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation; Belongs to the class [...] | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.589 |
| RNF222 | SAMD1 | ENSP00000382330 | ENSP00000431971 | Ring finger protein 222 | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | 0.627 |
| SAMD1 | C19orf57 | ENSP00000431971 | ENSP00000254336 | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57 | 0.527 |
