node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf44 | C11orf48 | ENSP00000485399 | ENSP00000436848 | Uncharacterized protein C11orf44; Chromosome 11 open reading frame 44 | LBH domain-containing protein 1; Chromosome 11 open reading frame 48 | 0.733 |
C11orf44 | METTL12 | ENSP00000485399 | ENSP00000431287 | Uncharacterized protein C11orf44; Chromosome 11 open reading frame 44 | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | 0.668 |
C11orf48 | C11orf44 | ENSP00000436848 | ENSP00000485399 | LBH domain-containing protein 1; Chromosome 11 open reading frame 48 | Uncharacterized protein C11orf44; Chromosome 11 open reading frame 44 | 0.733 |
C11orf48 | METTL12 | ENSP00000436848 | ENSP00000431287 | LBH domain-containing protein 1; Chromosome 11 open reading frame 48 | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | 0.642 |
ECE2 | FAM173A | ENSP00000384223 | ENSP00000454380 | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | Protein FAM173A; Seven-beta-strand methyltransferase motif containing | 0.468 |
ECE2 | METTL10 | ENSP00000384223 | ENSP00000357829 | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | 0.723 |
ECE2 | METTL12 | ENSP00000384223 | ENSP00000431287 | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | 0.627 |
ECE2 | METTL20 | ENSP00000384223 | ENSP00000350353 | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain | 0.527 |
ECE2 | NDUFAF5 | ENSP00000384223 | ENSP00000367346 | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | Arginine-hydroxylase NDUFAF5, mitochondrial; Arginine hydroxylase involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of ’Arg-111’ of NDUFS7. May also have methyltransferase activity (Probable) | 0.583 |
ECE2 | NDUFAF7 | ENSP00000384223 | ENSP00000002125 | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | Protein arginine methyltransferase NDUFAF7, mitochondrial; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of ’Arg-118’ of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex; Belongs to the NDUFAF7 family | 0.628 |
ECE2 | NDUFS7 | ENSP00000384223 | ENSP00000233627 | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.480 |
FAM173A | ECE2 | ENSP00000454380 | ENSP00000384223 | Protein FAM173A; Seven-beta-strand methyltransferase motif containing | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | 0.468 |
FAM173A | METTL10 | ENSP00000454380 | ENSP00000357829 | Protein FAM173A; Seven-beta-strand methyltransferase motif containing | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | 0.609 |
FAM173A | METTL12 | ENSP00000454380 | ENSP00000431287 | Protein FAM173A; Seven-beta-strand methyltransferase motif containing | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | 0.656 |
FAM173A | METTL20 | ENSP00000454380 | ENSP00000350353 | Protein FAM173A; Seven-beta-strand methyltransferase motif containing | Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain | 0.610 |
METTL10 | ECE2 | ENSP00000357829 | ENSP00000384223 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit amyloid- beta peptide accumulation in brain. May also have methyltransferase activity | 0.723 |
METTL10 | FAM173A | ENSP00000357829 | ENSP00000454380 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Protein FAM173A; Seven-beta-strand methyltransferase motif containing | 0.609 |
METTL10 | METTL12 | ENSP00000357829 | ENSP00000431287 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | 0.802 |
METTL10 | METTL20 | ENSP00000357829 | ENSP00000350353 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain | 0.811 |
METTL10 | MTRF1L | ENSP00000357829 | ENSP00000356202 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Peptide chain release factor 1-like, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG | 0.566 |