PCDHGA1 protein (human) - STRING database

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PCDHGA1

Protocadherin gamma-A1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (931 aa)

Predicted Functional Partners:

OR4K14

0.578

OR4N5

0.545

C11orf80

0.503

ATP8A2

0.455

PABPC5

0.438

TMEM132C

0.433

ZNF473

0.431

IZUMO2

0.426

KLHL4

0.423

CCDC85A

0.419

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP8A2	PCDHGA1	ENSP00000371070	ENSP00000431083	Phospholipid-transporting ATPase IB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2-TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). [...]	Protocadherin gamma-A1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins	0.455
C11orf80	CCDC85A	ENSP00000354227	ENSP00000384040	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	0.600
C11orf80	IZUMO2	ENSP00000354227	ENSP00000293405	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.480
C11orf80	KLHL4	ENSP00000354227	ENSP00000362206	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Kelch-like protein 4; Kelch like family member 4; BTB domain containing	0.636
C11orf80	OR4K14	ENSP00000354227	ENSP00000305011	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4	0.726
C11orf80	OR4N5	ENSP00000354227	ENSP00000332110	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4	0.712
C11orf80	PABPC5	ENSP00000354227	ENSP00000308012	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Polyadenylate-binding protein 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity); RNA binding motif containing	0.572
C11orf80	PCDHGA1	ENSP00000354227	ENSP00000431083	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Protocadherin gamma-A1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins	0.503
C11orf80	TMEM132C	ENSP00000354227	ENSP00000410852	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits	0.683
C11orf80	ZNF473	ENSP00000354227	ENSP00000472808	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases; Zinc fingers C2H2-type	0.668
CCDC85A	C11orf80	ENSP00000384040	ENSP00000354227	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	0.600
CCDC85A	KLHL4	ENSP00000384040	ENSP00000362206	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Kelch-like protein 4; Kelch like family member 4; BTB domain containing	0.552
CCDC85A	OR4K14	ENSP00000384040	ENSP00000305011	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4	0.609
CCDC85A	OR4N5	ENSP00000384040	ENSP00000332110	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4	0.577
CCDC85A	PABPC5	ENSP00000384040	ENSP00000308012	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Polyadenylate-binding protein 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity); RNA binding motif containing	0.534
CCDC85A	PCDHGA1	ENSP00000384040	ENSP00000431083	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Protocadherin gamma-A1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins	0.419
CCDC85A	TMEM132C	ENSP00000384040	ENSP00000410852	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits	0.620
CCDC85A	ZNF473	ENSP00000384040	ENSP00000472808	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases; Zinc fingers C2H2-type	0.547
IZUMO2	C11orf80	ENSP00000293405	ENSP00000354227	Izumo sperm-egg fusion protein 2; IZUMO family member 2	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	0.480
IZUMO2	OR4K14	ENSP00000293405	ENSP00000305011	Izumo sperm-egg fusion protein 2; IZUMO family member 2	Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4	0.559

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