HMGB4 protein (human) - STRING database

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Score

HMGB4

Canonical high mobility group; Belongs to the HMGB family (186 aa)

Predicted Functional Partners:

SOX4

0.609

FAM71B

0.561

C10orf82

0.531

ZBTB34

0.526

DNAJC5G

0.522

AUH

0.522

SHCBP1L

0.491

C1orf141

0.482

ACTL9

0.468

ZBTB18

0.465

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTL9	C1orf141	ENSP00000316674	ENSP00000360046	Actin-like protein 9; Actin related proteins	Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141	0.664
ACTL9	DNAJC5G	ENSP00000316674	ENSP00000296097	Actin-like protein 9; Actin related proteins	DnaJ heat shock protein family member C5 gamma	0.500
ACTL9	HMGB4	ENSP00000316674	ENSP00000430919	Actin-like protein 9; Actin related proteins	Canonical high mobility group; Belongs to the HMGB family	0.468
ACTL9	SHCBP1L	ENSP00000316674	ENSP00000356518	Actin-like protein 9; Actin related proteins	Testicular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells	0.681
AUH	HMGB4	ENSP00000364883	ENSP00000430919	Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs	Canonical high mobility group; Belongs to the HMGB family	0.522
AUH	ZBTB18	ENSP00000364883	ENSP00000351539	Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs	Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5’- [AC]ACATCTG[GT][AC]-3’ which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...]	0.467
AUH	ZBTB34	ENSP00000364883	ENSP00000362551	Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs	Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing	0.573
C10orf82	FAM71B	ENSP00000358212	ENSP00000305596	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82	Protein FAM71B; May be involved in RNA biogenesis	0.634
C10orf82	HMGB4	ENSP00000358212	ENSP00000430919	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82	Canonical high mobility group; Belongs to the HMGB family	0.531
C1orf141	ACTL9	ENSP00000360046	ENSP00000316674	Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141	Actin-like protein 9; Actin related proteins	0.664
C1orf141	DNAJC5G	ENSP00000360046	ENSP00000296097	Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141	DnaJ heat shock protein family member C5 gamma	0.489
C1orf141	HMGB4	ENSP00000360046	ENSP00000430919	Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141	Canonical high mobility group; Belongs to the HMGB family	0.482
C1orf141	SHCBP1L	ENSP00000360046	ENSP00000356518	Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141	Testicular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells	0.688
DNAJC5G	ACTL9	ENSP00000296097	ENSP00000316674	DnaJ heat shock protein family member C5 gamma	Actin-like protein 9; Actin related proteins	0.500
DNAJC5G	C1orf141	ENSP00000296097	ENSP00000360046	DnaJ heat shock protein family member C5 gamma	Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141	0.489
DNAJC5G	HMGB4	ENSP00000296097	ENSP00000430919	DnaJ heat shock protein family member C5 gamma	Canonical high mobility group; Belongs to the HMGB family	0.522
DNAJC5G	SHCBP1L	ENSP00000296097	ENSP00000356518	DnaJ heat shock protein family member C5 gamma	Testicular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells	0.535
FAM71B	C10orf82	ENSP00000305596	ENSP00000358212	Protein FAM71B; May be involved in RNA biogenesis	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82	0.634
FAM71B	HMGB4	ENSP00000305596	ENSP00000430919	Protein FAM71B; May be involved in RNA biogenesis	Canonical high mobility group; Belongs to the HMGB family	0.561
HMGB4	ACTL9	ENSP00000430919	ENSP00000316674	Canonical high mobility group; Belongs to the HMGB family	Actin-like protein 9; Actin related proteins	0.468

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