SCUBE2 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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SCUBE2

Signal peptide, CUB domain and EGF like domain containing 2 (971 aa)

Predicted Functional Partners:

SHH

0.941

IHH

0.922

DHH

0.919

DISP2

0.904

ST5

0.832

FOXR2

0.723

CNTD2

0.722

ADAL

0.714

TBC1D8B

0.714

CTSV

0.669

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAL	CNTD2	ENSP00000398744	ENSP00000396755	Adenosine deaminase-like protein; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity)	Cyclin N-terminal domain containing 2	0.763
ADAL	FOXR2	ENSP00000398744	ENSP00000427329	Adenosine deaminase-like protein; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity)	Forkhead box R2	0.754
ADAL	SCUBE2	ENSP00000398744	ENSP00000429969	Adenosine deaminase-like protein; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity)	Signal peptide, CUB domain and EGF like domain containing 2	0.714
ADAL	TBC1D8B	ENSP00000398744	ENSP00000349781	Adenosine deaminase-like protein; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity)	TBC1 domain family member 8B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing	0.746
CNTD2	ADAL	ENSP00000396755	ENSP00000398744	Cyclin N-terminal domain containing 2	Adenosine deaminase-like protein; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity)	0.763
CNTD2	FOXR2	ENSP00000396755	ENSP00000427329	Cyclin N-terminal domain containing 2	Forkhead box R2	0.753
CNTD2	SCUBE2	ENSP00000396755	ENSP00000429969	Cyclin N-terminal domain containing 2	Signal peptide, CUB domain and EGF like domain containing 2	0.722
CNTD2	TBC1D8B	ENSP00000396755	ENSP00000349781	Cyclin N-terminal domain containing 2	TBC1 domain family member 8B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing	0.771
CTSV	SCUBE2	ENSP00000445052	ENSP00000429969	Cathepsin L2; Cysteine protease. May have an important role in corneal physiology; Belongs to the peptidase C1 family	Signal peptide, CUB domain and EGF like domain containing 2	0.669
DHH	DISP2	ENSP00000266991	ENSP00000267889	Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family	Dispatched RND transporter family member 2	0.957
DHH	IHH	ENSP00000266991	ENSP00000295731	Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family	Indian hedgehog protein; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity); Belongs to the hedgehog family	0.903
DHH	SCUBE2	ENSP00000266991	ENSP00000429969	Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family	Signal peptide, CUB domain and EGF like domain containing 2	0.919
DHH	SHH	ENSP00000266991	ENSP00000297261	Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family	Sonic hedgehog protein; Sonic hedgehog protein- The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity); Hedgehog signaling molecule family	0.903
DISP2	DHH	ENSP00000267889	ENSP00000266991	Dispatched RND transporter family member 2	Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development; Hedgehog signaling molecule family	0.957
DISP2	IHH	ENSP00000267889	ENSP00000295731	Dispatched RND transporter family member 2	Indian hedgehog protein; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity); Belongs to the hedgehog family	0.957
DISP2	SCUBE2	ENSP00000267889	ENSP00000429969	Dispatched RND transporter family member 2	Signal peptide, CUB domain and EGF like domain containing 2	0.904
DISP2	SHH	ENSP00000267889	ENSP00000297261	Dispatched RND transporter family member 2	Sonic hedgehog protein; Sonic hedgehog protein- The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity); Hedgehog signaling molecule family	0.964
FOXR2	ADAL	ENSP00000427329	ENSP00000398744	Forkhead box R2	Adenosine deaminase-like protein; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity)	0.754
FOXR2	CNTD2	ENSP00000427329	ENSP00000396755	Forkhead box R2	Cyclin N-terminal domain containing 2	0.753
FOXR2	SCUBE2	ENSP00000427329	ENSP00000429969	Forkhead box R2	Signal peptide, CUB domain and EGF like domain containing 2	0.723

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