• Version:
  • 11.0 [archived version]
STRINGSTRING
PSG3 PSG3 NYAP2 NYAP2 ANKRD46 ANKRD46 CARS CARS RHBDD1 RHBDD1 FBXO24 FBXO24 ANKRD10 ANKRD10 ACAP1 ACAP1 RNF214 RNF214 AGFG2 AGFG2 NYAP1 NYAP1
"ANKRD46" - Ankyrin repeat domain-containing protein 46 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
ANKRD46Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing (232 aa)    
Predicted Functional Partners:
PSG3
Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family (428 aa)
       
      0.813
FBXO24
F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other (618 aa)
     
 
  0.780
ANKRD10
Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing (420 aa)
       
 
  0.759
RNF214
Ring finger protein 214 (703 aa)
           
  0.759
NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (653 aa)
     
   
  0.750
ACAP1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration; Ankyrin repeat domain containing (740 aa)
       
 
  0.748
CARS
Cysteine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class I; Belongs to the class-I aminoacyl-tRNA synthetase family (831 aa)
     
   
  0.695
NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis; Belongs to the NYAP family (841 aa)
     
   
  0.670
AGFG2
Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2; ArfGAPs (481 aa)
       
 
  0.660
RHBDD1
Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] (315 aa)
           
  0.626
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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