| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AADAC | CES5A | ENSP00000232892 | ENSP00000428864 | Arylacetamide deacetylase; Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity; Arylacetamide deacetylase family | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | 0.619 |
| ASGR1 | CES5A | ENSP00000269299 | ENSP00000428864 | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface; C-type lectin domain containing | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | 0.649 |
| ASGR1 | SPANXC | ENSP00000269299 | ENSP00000351884 | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface; C-type lectin domain containing | Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family | 0.640 |
| ASGR1 | UGT1A9 | ENSP00000269299 | ENSP00000346768 | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface; C-type lectin domain containing | UDP-glucuronosyltransferase 1-9; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 | 0.511 |
| CES5A | AADAC | ENSP00000428864 | ENSP00000232892 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | Arylacetamide deacetylase; Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity; Arylacetamide deacetylase family | 0.619 |
| CES5A | ASGR1 | ENSP00000428864 | ENSP00000269299 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface; C-type lectin domain containing | 0.649 |
| CES5A | ESD | ENSP00000428864 | ENSP00000367992 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde | 0.647 |
| CES5A | HAGH | ENSP00000428864 | ENSP00000380514 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.654 |
| CES5A | HPGDS | ENSP00000428864 | ENSP00000295256 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide; Belongs to the GST superfamily. Sigma family | 0.670 |
| CES5A | LRAT | ENSP00000428864 | ENSP00000337224 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments; [...] | 0.917 |
| CES5A | RBP4 | ENSP00000428864 | ENSP00000360522 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane; Belongs to the calycin superfamily. Lipocalin family | 0.906 |
| CES5A | SPANXC | ENSP00000428864 | ENSP00000351884 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family | 0.717 |
| CES5A | TOP1 | ENSP00000428864 | ENSP00000354522 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5’-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus remov [...] | 0.643 |
| CES5A | UGT1A9 | ENSP00000428864 | ENSP00000346768 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | UDP-glucuronosyltransferase 1-9; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 | 0.635 |
| ESD | CES5A | ENSP00000367992 | ENSP00000428864 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | 0.647 |
| ESD | HAGH | ENSP00000367992 | ENSP00000380514 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde | Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.783 |
| HAGH | CES5A | ENSP00000380514 | ENSP00000428864 | Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | 0.654 |
| HAGH | ESD | ENSP00000380514 | ENSP00000367992 | Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde | 0.783 |
| HAGH | HPGDS | ENSP00000380514 | ENSP00000295256 | Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide; Belongs to the GST superfamily. Sigma family | 0.428 |
| HPGDS | CES5A | ENSP00000295256 | ENSP00000428864 | Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide; Belongs to the GST superfamily. Sigma family | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases | 0.670 |
