| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALKBH1 | VASH2 | ENSP00000216489 | ENSP00000428324 | Nucleic acid dioxygenase ALKBH1; Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment. Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs. Acts as a regulator o [...] | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.448 |
| C7orf69 | VASH2 | ENSP00000258776 | ENSP00000428324 | Uncharacterized protein C7orf69; Chromosome 7 open reading frame 69 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.585 |
| CCDC23 | VASH2 | ENSP00000361599 | ENSP00000428324 | Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.775 |
| DLEC1 | VASH2 | ENSP00000308597 | ENSP00000428324 | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.452 |
| FGD5 | VASH2 | ENSP00000285046 | ENSP00000428324 | FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape; Pleckstrin homology domain containing | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.451 |
| FGF13 | MMP2 | ENSP00000322390 | ENSP00000219070 | Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus; Belongs to the heparin-binding growth factors family | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3b [...] | 0.511 |
| FGF13 | VASH2 | ENSP00000322390 | ENSP00000428324 | Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus; Belongs to the heparin-binding growth factors family | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.469 |
| MMP2 | FGF13 | ENSP00000219070 | ENSP00000322390 | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3b [...] | Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus; Belongs to the heparin-binding growth factors family | 0.511 |
| MMP2 | VASH2 | ENSP00000219070 | ENSP00000428324 | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3b [...] | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.456 |
| MSH4 | VASH2 | ENSP00000263187 | ENSP00000428324 | MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.503 |
| RRM2 | VASH2 | ENSP00000353770 | ENSP00000428324 | Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling; Belongs to the ribonucleoside diphosphate reductase small chain family | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.510 |
| TP73 | VASH2 | ENSP00000367545 | ENSP00000428324 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 0.490 |
| VASH2 | ALKBH1 | ENSP00000428324 | ENSP00000216489 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | Nucleic acid dioxygenase ALKBH1; Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment. Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs. Acts as a regulator o [...] | 0.448 |
| VASH2 | C7orf69 | ENSP00000428324 | ENSP00000258776 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | Uncharacterized protein C7orf69; Chromosome 7 open reading frame 69 | 0.585 |
| VASH2 | CCDC23 | ENSP00000428324 | ENSP00000361599 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2 | 0.775 |
| VASH2 | DLEC1 | ENSP00000428324 | ENSP00000308597 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated | 0.452 |
| VASH2 | FGD5 | ENSP00000428324 | ENSP00000285046 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape; Pleckstrin homology domain containing | 0.451 |
| VASH2 | FGF13 | ENSP00000428324 | ENSP00000322390 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus; Belongs to the heparin-binding growth factors family | 0.469 |
| VASH2 | MMP2 | ENSP00000428324 | ENSP00000219070 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3b [...] | 0.456 |
| VASH2 | MSH4 | ENSP00000428324 | ENSP00000263187 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family | MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family | 0.503 |
