| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LEPR | LEPROTL1 | ENSP00000330393 | ENSP00000428281 | Leptin receptor; Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity). In the periphery, increases basal metabolism, influences [...] | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | 0.623 |
| LEPROTL1 | LEPR | ENSP00000428281 | ENSP00000330393 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Leptin receptor; Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity). In the periphery, increases basal metabolism, influences [...] | 0.623 |
| LEPROTL1 | RAB11B | ENSP00000428281 | ENSP00000333547 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epitheli [...] | 0.555 |
| LEPROTL1 | RAB13 | ENSP00000428281 | ENSP00000357564 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] | 0.767 |
| LEPROTL1 | RSPRY1 | ENSP00000428281 | ENSP00000443176 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Ring finger and SPRY domain containing 1 | 0.720 |
| LEPROTL1 | SGCZ | ENSP00000428281 | ENSP00000371512 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Zeta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity) | 0.555 |
| LEPROTL1 | SMEK1 | ENSP00000428281 | ENSP00000450864 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on ’Ser-140’ (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair; Belongs to the SMEK family | 0.647 |
| LEPROTL1 | TM4SF19 | ENSP00000428281 | ENSP00000273695 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family | 0.729 |
| LEPROTL1 | TMEM50A | ENSP00000428281 | ENSP00000363478 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Transmembrane protein 50A | 0.692 |
| LEPROTL1 | TMEM50B | ENSP00000428281 | ENSP00000439768 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Transmembrane protein 50B | 0.710 |
| LEPROTL1 | TUT1 | ENSP00000428281 | ENSP00000308000 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3’-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3’-end cleavage of pre-mRNAs- binds to the 3’UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3’UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher tha [...] | 0.675 |
| RAB11B | LEPROTL1 | ENSP00000333547 | ENSP00000428281 | Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epitheli [...] | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | 0.555 |
| RAB11B | RAB13 | ENSP00000333547 | ENSP00000357564 | Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epitheli [...] | Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] | 0.908 |
| RAB13 | LEPROTL1 | ENSP00000357564 | ENSP00000428281 | Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | 0.767 |
| RAB13 | RAB11B | ENSP00000357564 | ENSP00000333547 | Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] | Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epitheli [...] | 0.908 |
| RSPRY1 | LEPROTL1 | ENSP00000443176 | ENSP00000428281 | Ring finger and SPRY domain containing 1 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | 0.720 |
| RSPRY1 | TUT1 | ENSP00000443176 | ENSP00000308000 | Ring finger and SPRY domain containing 1 | Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3’-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3’-end cleavage of pre-mRNAs- binds to the 3’UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3’UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher tha [...] | 0.731 |
| SGCZ | LEPROTL1 | ENSP00000371512 | ENSP00000428281 | Zeta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity) | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | 0.555 |
| SMEK1 | LEPROTL1 | ENSP00000450864 | ENSP00000428281 | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on ’Ser-140’ (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair; Belongs to the SMEK family | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family | 0.647 |
| SMEK1 | TM4SF19 | ENSP00000450864 | ENSP00000273695 | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on ’Ser-140’ (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair; Belongs to the SMEK family | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family | 0.712 |
