| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKHD1 | EIF4EBP3 | ENSP00000354085 | ENSP00000308472 | Ankyrin repeat and KH domain-containing protein 1; May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases; Belongs to the mask family | Eukaryotic translation initiation factor 4E-binding protein 3; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex- hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation | 0.758 |
| ANKHD1 | SLC4A9 | ENSP00000354085 | ENSP00000427661 | Ankyrin repeat and KH domain-containing protein 1; May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases; Belongs to the mask family | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.749 |
| EIF4EBP3 | ANKHD1 | ENSP00000308472 | ENSP00000354085 | Eukaryotic translation initiation factor 4E-binding protein 3; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex- hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation | Ankyrin repeat and KH domain-containing protein 1; May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases; Belongs to the mask family | 0.758 |
| EIF4EBP3 | SLC4A9 | ENSP00000308472 | ENSP00000427661 | Eukaryotic translation initiation factor 4E-binding protein 3; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex- hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.547 |
| GYPA | LIMS1 | ENSP00000354003 | ENSP00000446121 | Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for [...] | LIM and senescent cell antigen-like-containing domain protein 1; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation; LIM domain containing | 0.623 |
| GYPA | SLC4A9 | ENSP00000354003 | ENSP00000427661 | Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for [...] | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.653 |
| H1F0 | SLC4A9 | ENSP00000344504 | ENSP00000427661 | Histone H1.0; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.570 |
| LIMS1 | GYPA | ENSP00000446121 | ENSP00000354003 | LIM and senescent cell antigen-like-containing domain protein 1; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation; LIM domain containing | Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for [...] | 0.623 |
| LIMS1 | SLC4A9 | ENSP00000446121 | ENSP00000427661 | LIM and senescent cell antigen-like-containing domain protein 1; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation; LIM domain containing | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.654 |
| SLC26A3 | SLC4A9 | ENSP00000345873 | ENSP00000427661 | Chloride anion exchanger; Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation; Solute carriers | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.602 |
| SLC26A4 | SLC4A9 | ENSP00000265715 | ENSP00000427661 | Pendrin; Sodium-independent transporter of chloride and iodide; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.570 |
| SLC26A6 | SLC4A9 | ENSP00000378920 | ENSP00000427661 | Solute carrier family 26 member 6; Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride- fo [...] | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.581 |
| SLC26A7 | SLC4A9 | ENSP00000309504 | ENSP00000427661 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion; Solute carriers | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.573 |
| SLC26A9 | SLC4A9 | ENSP00000356102 | ENSP00000427661 | Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | 0.513 |
| SLC4A9 | ANKHD1 | ENSP00000427661 | ENSP00000354085 | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | Ankyrin repeat and KH domain-containing protein 1; May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases; Belongs to the mask family | 0.749 |
| SLC4A9 | EIF4EBP3 | ENSP00000427661 | ENSP00000308472 | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | Eukaryotic translation initiation factor 4E-binding protein 3; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex- hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation | 0.547 |
| SLC4A9 | GYPA | ENSP00000427661 | ENSP00000354003 | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for [...] | 0.653 |
| SLC4A9 | H1F0 | ENSP00000427661 | ENSP00000344504 | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | Histone H1.0; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division | 0.570 |
| SLC4A9 | LIMS1 | ENSP00000427661 | ENSP00000446121 | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | LIM and senescent cell antigen-like-containing domain protein 1; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation; LIM domain containing | 0.654 |
| SLC4A9 | SLC26A3 | ENSP00000427661 | ENSP00000345873 | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family | Chloride anion exchanger; Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation; Solute carriers | 0.602 |
