| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD13D | C1orf162 | ENSP00000427130 | ENSP00000344218 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Transmembrane protein C1orf162; Chromosome 1 open reading frame 162 | 0.615 |
| ANKRD13D | CRISPLD2 | ENSP00000427130 | ENSP00000262424 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | 0.625 |
| ANKRD13D | FAM189B | ENSP00000427130 | ENSP00000354958 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Protein FAM189B; Family with sequence similarity 189 member B | 0.539 |
| ANKRD13D | NECAB3 | ENSP00000427130 | ENSP00000246190 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3; EF-hand domain containing | 0.515 |
| ANKRD13D | NID2 | ENSP00000427130 | ENSP00000216286 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Nidogen-2; Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions | 0.510 |
| ANKRD13D | SORCS1 | ENSP00000427130 | ENSP00000263054 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Sortilin related VPS10 domain containing receptor 1; Belongs to the VPS10-related sortilin family. SORCS subfamily | 0.485 |
| ANKRD13D | SORL1 | ENSP00000427130 | ENSP00000260197 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Sortilin-related receptor; Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide [...] | 0.507 |
| ANKRD13D | TANC2 | ENSP00000427130 | ENSP00000387593 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Protein TANC2; Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2; Belongs to the TANC family | 0.551 |
| ANKRD13D | TSEN15 | ENSP00000427130 | ENSP00000355299 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | tRNA-splicing endonuclease subunit Sen15; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] | 0.477 |
| ANKRD13D | UNKL | ENSP00000427130 | ENSP00000301712 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family | 0.535 |
| C1orf162 | ANKRD13D | ENSP00000344218 | ENSP00000427130 | Transmembrane protein C1orf162; Chromosome 1 open reading frame 162 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.615 |
| C1orf162 | NECAB3 | ENSP00000344218 | ENSP00000246190 | Transmembrane protein C1orf162; Chromosome 1 open reading frame 162 | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3; EF-hand domain containing | 0.533 |
| C1orf162 | TSEN15 | ENSP00000344218 | ENSP00000355299 | Transmembrane protein C1orf162; Chromosome 1 open reading frame 162 | tRNA-splicing endonuclease subunit Sen15; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] | 0.511 |
| C1orf162 | UNKL | ENSP00000344218 | ENSP00000301712 | Transmembrane protein C1orf162; Chromosome 1 open reading frame 162 | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family | 0.555 |
| CRISPLD2 | ANKRD13D | ENSP00000262424 | ENSP00000427130 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.625 |
| FAM189B | ANKRD13D | ENSP00000354958 | ENSP00000427130 | Protein FAM189B; Family with sequence similarity 189 member B | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.539 |
| NECAB3 | ANKRD13D | ENSP00000246190 | ENSP00000427130 | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3; EF-hand domain containing | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.515 |
| NECAB3 | C1orf162 | ENSP00000246190 | ENSP00000344218 | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3; EF-hand domain containing | Transmembrane protein C1orf162; Chromosome 1 open reading frame 162 | 0.533 |
| NECAB3 | TSEN15 | ENSP00000246190 | ENSP00000355299 | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3; EF-hand domain containing | tRNA-splicing endonuclease subunit Sen15; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] | 0.404 |
| NECAB3 | UNKL | ENSP00000246190 | ENSP00000301712 | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3; EF-hand domain containing | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family | 0.445 |
