| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACVR2A | ASTE1 | ENSP00000241416 | ENSP00000426421 | Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | Protein asteroid homolog 1; Possible role in EGF receptor signaling | 0.476 |
| ACVR2A | MSH3 | ENSP00000241416 | ENSP00000265081 | Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | DNA mismatch repair protein Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, [...] | 0.520 |
| ASTE1 | ACVR2A | ENSP00000426421 | ENSP00000241416 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.476 |
| ASTE1 | ATP2C1 | ENSP00000426421 | ENSP00000421326 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily | 0.593 |
| ASTE1 | EPS8L2 | ENSP00000426421 | ENSP00000435585 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity); Belongs to the EPS8 family | 0.680 |
| ASTE1 | KIAA2018 | ENSP00000426421 | ENSP00000320794 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial- mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties | 0.530 |
| ASTE1 | LTN1 | ENSP00000426421 | ENSP00000478783 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity); Armadillo-like helical domain containing | 0.502 |
| ASTE1 | MSH3 | ENSP00000426421 | ENSP00000265081 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | DNA mismatch repair protein Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, [...] | 0.497 |
| ASTE1 | NABP1 | ENSP00000426421 | ENSP00000403683 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | 0.530 |
| ASTE1 | OR51A7 | ENSP00000426421 | ENSP00000352305 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | Olfactory receptor 51A7; Odorant receptor; Olfactory receptors, family 51 | 0.457 |
| ASTE1 | SREK1IP1 | ENSP00000426421 | ENSP00000427401 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival | 0.452 |
| ASTE1 | TAF1B | ENSP00000426421 | ENSP00000263663 | Protein asteroid homolog 1; Possible role in EGF receptor signaling | TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3; Belongs to the RRN7/TAF1B family | 0.718 |
| ATP2C1 | ASTE1 | ENSP00000421326 | ENSP00000426421 | Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily | Protein asteroid homolog 1; Possible role in EGF receptor signaling | 0.593 |
| EPS8L2 | ASTE1 | ENSP00000435585 | ENSP00000426421 | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity); Belongs to the EPS8 family | Protein asteroid homolog 1; Possible role in EGF receptor signaling | 0.680 |
| KIAA2018 | ASTE1 | ENSP00000320794 | ENSP00000426421 | Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial- mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties | Protein asteroid homolog 1; Possible role in EGF receptor signaling | 0.530 |
| KIAA2018 | OR51A7 | ENSP00000320794 | ENSP00000352305 | Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial- mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties | Olfactory receptor 51A7; Odorant receptor; Olfactory receptors, family 51 | 0.473 |
| LTN1 | ASTE1 | ENSP00000478783 | ENSP00000426421 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity); Armadillo-like helical domain containing | Protein asteroid homolog 1; Possible role in EGF receptor signaling | 0.502 |
| LTN1 | TAF1B | ENSP00000478783 | ENSP00000263663 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity); Armadillo-like helical domain containing | TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3; Belongs to the RRN7/TAF1B family | 0.450 |
| MSH3 | ACVR2A | ENSP00000265081 | ENSP00000241416 | DNA mismatch repair protein Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, [...] | Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.520 |
| MSH3 | ASTE1 | ENSP00000265081 | ENSP00000426421 | DNA mismatch repair protein Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, [...] | Protein asteroid homolog 1; Possible role in EGF receptor signaling | 0.497 |
