node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000197991 | SMPD3 | ENSP00000386653 | ENSP00000219334 | Protocadherin 20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization; Belongs to the neutral sphingomyelinase family | 0.480 |
ENSG00000197991 | SNX25 | ENSP00000386653 | ENSP00000426255 | Protocadherin 20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.607 |
ENSG00000197991 | TAPT1 | ENSP00000386653 | ENSP00000385347 | Protocadherin 20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity) | 0.512 |
HSPB8 | KIF1B | ENSP00000281938 | ENSP00000263934 | Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family | Kinesin-like protein KIF1B; Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis; Kinesins | 0.519 |
HSPB8 | SNX25 | ENSP00000281938 | ENSP00000426255 | Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.752 |
KIF1B | HSPB8 | ENSP00000263934 | ENSP00000281938 | Kinesin-like protein KIF1B; Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis; Kinesins | Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family | 0.519 |
KIF1B | SNX25 | ENSP00000263934 | ENSP00000426255 | Kinesin-like protein KIF1B; Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis; Kinesins | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.657 |
PCDH13 | SMPD3 | ENSP00000387250 | ENSP00000219334 | Protocadherin-20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization; Belongs to the neutral sphingomyelinase family | 0.480 |
PCDH13 | SNX25 | ENSP00000387250 | ENSP00000426255 | Protocadherin-20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.607 |
PCDH13 | TAPT1 | ENSP00000387250 | ENSP00000385347 | Protocadherin-20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity) | 0.512 |
SAMD12 | SNX25 | ENSP00000314173 | ENSP00000426255 | Sterile alpha motif domain containing 12 | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.679 |
SMPD3 | ENSG00000197991 | ENSP00000219334 | ENSP00000386653 | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization; Belongs to the neutral sphingomyelinase family | Protocadherin 20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | 0.480 |
SMPD3 | PCDH13 | ENSP00000219334 | ENSP00000387250 | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization; Belongs to the neutral sphingomyelinase family | Protocadherin-20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | 0.480 |
SMPD3 | SNX25 | ENSP00000219334 | ENSP00000426255 | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization; Belongs to the neutral sphingomyelinase family | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.623 |
SMPD3 | TAPT1 | ENSP00000219334 | ENSP00000385347 | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization; Belongs to the neutral sphingomyelinase family | Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity) | 0.464 |
SNX17 | SNX21 | ENSP00000233575 | ENSP00000418593 | Sorting nexin-17; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) | Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.771 |
SNX17 | SNX25 | ENSP00000233575 | ENSP00000426255 | Sorting nexin-17; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.624 |
SNX21 | SNX17 | ENSP00000418593 | ENSP00000233575 | Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | Sorting nexin-17; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) | 0.771 |
SNX21 | SNX25 | ENSP00000418593 | ENSP00000426255 | Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.682 |
SNX21 | SNX27 | ENSP00000418593 | ENSP00000357836 | Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus- following interaction with target transmembrane proteins, associates with the retromer complex, preventing e [...] | 0.534 |