C6orf223 protein (human) - STRING database

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C6orf223

Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223 (242 aa)

Predicted Functional Partners:

KCNV2

0.642

ZADH2

0.571

MRPL14

0.553

KRTAP5-7

0.479

KLHL29

0.476

TMEM171

0.473

ZFPM2

0.473

JMJD1C

0.420

FGD6

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6orf223	FGD6	ENSP00000426159	ENSP00000344446	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing	0.410
C6orf223	JMJD1C	ENSP00000426159	ENSP00000382204	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	Probable JmjC domain-containing histone demethylation protein 2C; Probable histone demethylase that specifically demethylates ’Lys-9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity); Lysine demethylases	0.420
C6orf223	KCNV2	ENSP00000426159	ENSP00000371514	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	Potassium voltage-gated channel subfamily V member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily	0.642
C6orf223	KLHL29	ENSP00000426159	ENSP00000420659	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	Kelch-like protein 29; Kelch like family member 29; BTB domain containing	0.476
C6orf223	KRTAP5-7	ENSP00000426159	ENSP00000417330	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	Keratin-associated protein 5-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family	0.479
C6orf223	MRPL14	ENSP00000426159	ENSP00000361084	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	39S ribosomal protein L14, mitochondrial; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable); Mitochondrial ribosomal proteins	0.553
C6orf223	TMEM171	ENSP00000426159	ENSP00000415030	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	Transmembrane protein 171	0.473
C6orf223	ZADH2	ENSP00000426159	ENSP00000323678	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	Prostaglandin reductase 3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	0.571
C6orf223	ZFPM2	ENSP00000426159	ENSP00000384179	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	Zinc finger protein ZFPM2; Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By sim [...]	0.473
FGD6	C6orf223	ENSP00000344446	ENSP00000426159	FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.410
JMJD1C	C6orf223	ENSP00000382204	ENSP00000426159	Probable JmjC domain-containing histone demethylation protein 2C; Probable histone demethylase that specifically demethylates ’Lys-9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity); Lysine demethylases	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.420
KCNV2	C6orf223	ENSP00000371514	ENSP00000426159	Potassium voltage-gated channel subfamily V member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.642
KLHL29	C6orf223	ENSP00000420659	ENSP00000426159	Kelch-like protein 29; Kelch like family member 29; BTB domain containing	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.476
KRTAP5-7	C6orf223	ENSP00000417330	ENSP00000426159	Keratin-associated protein 5-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.479
MRPL14	C6orf223	ENSP00000361084	ENSP00000426159	39S ribosomal protein L14, mitochondrial; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable); Mitochondrial ribosomal proteins	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.553
TMEM171	C6orf223	ENSP00000415030	ENSP00000426159	Transmembrane protein 171	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.473
ZADH2	C6orf223	ENSP00000323678	ENSP00000426159	Prostaglandin reductase 3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.571
ZFPM2	C6orf223	ENSP00000384179	ENSP00000426159	Zinc finger protein ZFPM2; Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By sim [...]	Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223	0.473

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