CRIP2 protein (human) - STRING database

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CRIP2

Cysteine rich protein 2; LIM domain containing (282 aa)

Predicted Functional Partners:

GLIPR2

0.672

HMG20B

0.664

PRKG1

0.660

KANK3

0.565

BCAR1

0.557

TMEM121

0.549

SRF

0.523

RHPN2

0.497

ACOT6

0.485

NUDT14

0.458

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOT6	CRIP2	ENSP00000370531	ENSP00000426119	acyl-CoA thioesterase 6	Cysteine rich protein 2; LIM domain containing	0.485
BCAR1	CRIP2	ENSP00000391669	ENSP00000426119	Breast cancer anti-estrogen resistance protein 1; Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells; Cas scaffolding proteins	Cysteine rich protein 2; LIM domain containing	0.557
CRIP2	ACOT6	ENSP00000426119	ENSP00000370531	Cysteine rich protein 2; LIM domain containing	acyl-CoA thioesterase 6	0.485
CRIP2	BCAR1	ENSP00000426119	ENSP00000391669	Cysteine rich protein 2; LIM domain containing	Breast cancer anti-estrogen resistance protein 1; Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells; Cas scaffolding proteins	0.557
CRIP2	GLIPR2	ENSP00000426119	ENSP00000367196	Cysteine rich protein 2; LIM domain containing	Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily	0.672
CRIP2	HMG20B	ENSP00000426119	ENSP00000328269	Cysteine rich protein 2; LIM domain containing	High mobility group 20B; Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters; Non-canonical high mobility group	0.664
CRIP2	KANK3	ENSP00000426119	ENSP00000328923	Cysteine rich protein 2; LIM domain containing	KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization; Ankyrin repeat domain containing	0.565
CRIP2	NUDT14	ENSP00000426119	ENSP00000376349	Cysteine rich protein 2; LIM domain containing	Uridine diphosphate glucose pyrophosphatase; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose; Nudix hydrolase family	0.458
CRIP2	PRKG1	ENSP00000426119	ENSP00000363092	Cysteine rich protein 2; LIM domain containing	cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...]	0.660
CRIP2	RHPN2	ENSP00000426119	ENSP00000254260	Cysteine rich protein 2; LIM domain containing	Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family	0.497
CRIP2	SRF	ENSP00000426119	ENSP00000265354	Cysteine rich protein 2; LIM domain containing	Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation; MADS box family	0.523
CRIP2	TMEM121	ENSP00000426119	ENSP00000376304	Cysteine rich protein 2; LIM domain containing	Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family	0.549
GLIPR2	CRIP2	ENSP00000367196	ENSP00000426119	Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily	Cysteine rich protein 2; LIM domain containing	0.672
HMG20B	CRIP2	ENSP00000328269	ENSP00000426119	High mobility group 20B; Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters; Non-canonical high mobility group	Cysteine rich protein 2; LIM domain containing	0.664
KANK3	CRIP2	ENSP00000328923	ENSP00000426119	KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization; Ankyrin repeat domain containing	Cysteine rich protein 2; LIM domain containing	0.565
NUDT14	CRIP2	ENSP00000376349	ENSP00000426119	Uridine diphosphate glucose pyrophosphatase; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose; Nudix hydrolase family	Cysteine rich protein 2; LIM domain containing	0.458
NUDT14	TMEM121	ENSP00000376349	ENSP00000376304	Uridine diphosphate glucose pyrophosphatase; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose; Nudix hydrolase family	Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family	0.424
PRKG1	CRIP2	ENSP00000363092	ENSP00000426119	cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...]	Cysteine rich protein 2; LIM domain containing	0.660
RHPN2	CRIP2	ENSP00000254260	ENSP00000426119	Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family	Cysteine rich protein 2; LIM domain containing	0.497
SRF	CRIP2	ENSP00000265354	ENSP00000426119	Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation; MADS box family	Cysteine rich protein 2; LIM domain containing	0.523

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