• Version:
  • 11.0 [archived version]
STRINGSTRING
DEFA3 DEFA3 DEFA5 DEFA5 DEFA4 DEFA4 DEFB1 DEFB1 CAMP CAMP DEFB4B DEFB4B SPAG11B SPAG11B DEFB4A DEFB4A DEFB104B DEFB104B S100A7 S100A7 SPAG11A SPAG11A
"DEFB4B" - Beta-defensin 4A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
DEFB4BBeta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells; Belongs to the beta-defensin family. LAP/TAP subfamily (64 aa)    
Predicted Functional Partners:
DEFB4A
Defensin, beta 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells; Defensins, beta (64 aa)
     
 
0.913
SPAG11B
Sperm-associated antigen 11A; Sperm associated antigen 11B; Belongs to the SPAG11 family (133 aa)
           
  0.742
SPAG11A
Sperm associated antigen 11A; Belongs to the SPAG11 family (108 aa)
           
  0.742
DEFB1
Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family (68 aa)
           
  0.679
DEFA3
Neutrophil defensin 3; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane; Defensins, alpha (94 aa)
           
  0.626
DEFA4
Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production; Defensins, alpha (97 aa)
           
  0.625
S100A7
S100 calcium binding protein A7; EF-hand domain containing (101 aa)
     
   
  0.601
DEFA5
Defensin-5; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing; Defensins, alpha (94 aa)
           
  0.580
CAMP
Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Endogenous ligands (173 aa)
           
  0.580
DEFB104B
Beta-defensin 104; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103; Belongs to the beta-defensin family (72 aa)
           
  0.560
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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