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  • 11.0 [archived version]
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SYNDIG1 SYNDIG1 OR5I1 OR5I1 PAK4 PAK4 DPY19L1 DPY19L1 VSTM2A VSTM2A TSHR TSHR SH3RF2 SH3RF2 ZCCHC24 ZCCHC24 CENPJ CENPJ PLAC8L1 PLAC8L1 SP4 SP4
"SH3RF2" - Putative E3 ubiquitin-protein ligase SH3RF2 in Homo sapiens
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second shell of interactors
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filled nodes:
some 3D structure is known or predicted
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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SH3RF2Putative E3 ubiquitin-protein ligase SH3RF2; Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function; Belongs to the SH3RF family (729 aa)    
Predicted Functional Partners:
ZCCHC24
Zinc finger CCHC-type containing 24; Zinc fingers 3CxxC-type (241 aa)
           
  0.701
CENPJ
Centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL- mediated centriole amplification. May be involved in the control of centriolar-microtubule growth by act [...] (1338 aa)
     
      0.689
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2-GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism (By similarity); Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily (764 aa)
     
   
  0.682
OR5I1
Olfactory receptor 5I1; Odorant receptor; Olfactory receptors, family 5 (314 aa)
           
  0.619
PAK4
Serine/threonine-protein kinase PAK 4; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin [...] (591 aa)
       
 
  0.617
DPY19L1
Probable C-mannosyltransferase DPY19L1; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (675 aa)
     
   
  0.571
VSTM2A
V-set and transmembrane domain-containing protein 2A; Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway; V-set domain containing (240 aa)
           
  0.569
PLAC8L1
PLAC8-like protein 1; PLAC8 like 1; Belongs to the cornifelin family (177 aa)
           
  0.547
SP4
Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator; Belongs to the Sp1 C2H2-type zinc-finger protein family (784 aa)
     
 
  0.546
SYNDIG1
Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation; Belongs to the CD225/Dispanin family (258 aa)
           
  0.545
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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