| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FYTTD1 | THUMPD2 | ENSP00000241502 | ENSP00000423933 | UAP56-interacting factor; Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | 0.635 |
| METTL2A | THUMPD2 | ENSP00000309610 | ENSP00000423933 | Methyltransferase-like protein 2A; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | 0.639 |
| METTL2A | TRMT1 | ENSP00000309610 | ENSP00000466967 | Methyltransferase-like protein 2A; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family | 0.419 |
| METTL2A | TRMT11 | ENSP00000309610 | ENSP00000333934 | Methyltransferase-like protein 2A; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs | 0.427 |
| METTL2B | THUMPD2 | ENSP00000262432 | ENSP00000423933 | Methyltransferase-like protein 2B; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | 0.572 |
| METTL2B | TRMT1 | ENSP00000262432 | ENSP00000466967 | Methyltransferase-like protein 2B; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family | 0.532 |
| METTL2B | TRMT11 | ENSP00000262432 | ENSP00000333934 | Methyltransferase-like protein 2B; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs | 0.593 |
| QTRTD1 | RPUSD1 | ENSP00000420682 | ENSP00000455026 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) | RNA pseudouridylate synthase domain containing 1; Belongs to the pseudouridine synthase RluA family | 0.562 |
| QTRTD1 | RPUSD2 | ENSP00000420682 | ENSP00000323288 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) | RNA pseudouridylate synthase domain containing 2 | 0.592 |
| QTRTD1 | THUMPD2 | ENSP00000420682 | ENSP00000423933 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | 0.632 |
| QTRTD1 | TRMT1 | ENSP00000420682 | ENSP00000466967 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) | tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family | 0.737 |
| QTRTD1 | TRMT11 | ENSP00000420682 | ENSP00000333934 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) | tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs | 0.440 |
| RPUSD1 | QTRTD1 | ENSP00000455026 | ENSP00000420682 | RNA pseudouridylate synthase domain containing 1; Belongs to the pseudouridine synthase RluA family | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) | 0.562 |
| RPUSD1 | THUMPD2 | ENSP00000455026 | ENSP00000423933 | RNA pseudouridylate synthase domain containing 1; Belongs to the pseudouridine synthase RluA family | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | 0.587 |
| RPUSD2 | QTRTD1 | ENSP00000323288 | ENSP00000420682 | RNA pseudouridylate synthase domain containing 2 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) | 0.592 |
| RPUSD2 | THUMPD2 | ENSP00000323288 | ENSP00000423933 | RNA pseudouridylate synthase domain containing 2 | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | 0.605 |
| SOS1 | THUMPD2 | ENSP00000387784 | ENSP00000423933 | Son of sevenless homolog 1; Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity); Pleckstrin homology domain containing | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | 0.714 |
| TATDN1 | THUMPD2 | ENSP00000276692 | ENSP00000423933 | Putative deoxyribonuclease TATDN1; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | 0.587 |
| THUMPD2 | FYTTD1 | ENSP00000423933 | ENSP00000241502 | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | UAP56-interacting factor; Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 | 0.635 |
| THUMPD2 | METTL2A | ENSP00000423933 | ENSP00000309610 | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily | Methyltransferase-like protein 2A; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | 0.639 |
