node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHX15 | PACRGL | ENSP00000336741 | ENSP00000423881 | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily | PACRG-like protein; Armadillo-like helical domain containing | 0.573 |
FAM184B | KCNIP4 | ENSP00000265018 | ENSP00000371587 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family | 0.514 |
FAM184B | PACRGL | ENSP00000265018 | ENSP00000423881 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family | PACRG-like protein; Armadillo-like helical domain containing | 0.715 |
GPR125 | KCNIP4 | ENSP00000334952 | ENSP00000371587 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family | 0.513 |
GPR125 | PACRGL | ENSP00000334952 | ENSP00000423881 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | PACRG-like protein; Armadillo-like helical domain containing | 0.736 |
IFT22 | PACRGL | ENSP00000320359 | ENSP00000423881 | Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B; Belongs to the small GTPase superfamily. Rab family | PACRG-like protein; Armadillo-like helical domain containing | 0.485 |
KCNIP4 | FAM184B | ENSP00000371587 | ENSP00000265018 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family | 0.514 |
KCNIP4 | GPR125 | ENSP00000371587 | ENSP00000334952 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.513 |
KCNIP4 | PACRGL | ENSP00000371587 | ENSP00000423881 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family | PACRG-like protein; Armadillo-like helical domain containing | 0.511 |
NTM | PACRGL | ENSP00000396722 | ENSP00000423881 | Neurotrimin; Neural cell adhesion molecule; Belongs to the immunoglobulin superfamily. IgLON family | PACRG-like protein; Armadillo-like helical domain containing | 0.496 |
PACRGL | DHX15 | ENSP00000423881 | ENSP00000336741 | PACRG-like protein; Armadillo-like helical domain containing | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily | 0.573 |
PACRGL | FAM184B | ENSP00000423881 | ENSP00000265018 | PACRG-like protein; Armadillo-like helical domain containing | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family | 0.715 |
PACRGL | GPR125 | ENSP00000423881 | ENSP00000334952 | PACRG-like protein; Armadillo-like helical domain containing | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.736 |
PACRGL | IFT22 | ENSP00000423881 | ENSP00000320359 | PACRG-like protein; Armadillo-like helical domain containing | Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B; Belongs to the small GTPase superfamily. Rab family | 0.485 |
PACRGL | KCNIP4 | ENSP00000423881 | ENSP00000371587 | PACRG-like protein; Armadillo-like helical domain containing | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family | 0.511 |
PACRGL | NTM | ENSP00000423881 | ENSP00000396722 | PACRG-like protein; Armadillo-like helical domain containing | Neurotrimin; Neural cell adhesion molecule; Belongs to the immunoglobulin superfamily. IgLON family | 0.496 |
PACRGL | PPARGC1A | ENSP00000423881 | ENSP00000264867 | PACRG-like protein; Armadillo-like helical domain containing | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.471 |
PACRGL | RSPH9 | ENSP00000423881 | ENSP00000361238 | PACRG-like protein; Armadillo-like helical domain containing | Radial spoke head 9 homolog | 0.447 |
PACRGL | SLIT2 | ENSP00000423881 | ENSP00000422591 | PACRG-like protein; Armadillo-like helical domain containing | Slit homolog 2 protein; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they [...] | 0.495 |
PACRGL | SNX19 | ENSP00000423881 | ENSP00000265909 | PACRG-like protein; Armadillo-like helical domain containing | Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity); Belongs to the sorting nexin family | 0.580 |