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  • 11.0 [archived version]
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MFSD11 MFSD11 MFSD10 MFSD10 MFSD8 MFSD8 MFSD5 MFSD5 SV2C SV2C SV2B SV2B UNC93A UNC93A GP2 GP2 SV2A SV2A LAMC2 LAMC2 SYT1 SYT1
"SV2C" - Synaptic vesicle glycoprotein 2C in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SV2CSynaptic vesicle glycoprotein 2C; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity) (727 aa)    
Predicted Functional Partners:
SV2B
Synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells (683 aa)
   
 
0.825
SV2A
Synaptic vesicle glycoprotein 2A; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity) (742 aa)
   
 
0.812
GP2
Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 2 (537 aa)
           
  0.802
MFSD11
UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family (449 aa)
           
  0.766
MFSD5
Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily (557 aa)
           
  0.755
SYT1
Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins (422 aa)
     
 
  0.753
MFSD10
Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (455 aa)
           
  0.730
UNC93A
Unc-93 homolog A; Belongs to the unc-93 family (457 aa)
           
  0.668
LAMC2
Laminin subunit gamma-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells (1193 aa)
         
  0.656
MFSD8
Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily (518 aa)
     
   
  0.650
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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