| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMCX3 | IMMP2L | ENSP00000340672 | ENSP00000384966 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2- kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Armadillo repeat containing | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | 0.682 |
| ARMCX3 | LRRC19 | ENSP00000340672 | ENSP00000369395 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2- kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Armadillo repeat containing | Leucine-rich repeat-containing protein 19; Leucine rich repeat containing 19 | 0.738 |
| ARMCX3 | TMEM214 | ENSP00000340672 | ENSP00000238788 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2- kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Armadillo repeat containing | Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress; Belongs to the TMEM214 family | 0.746 |
| ARMCX3 | TRMT11 | ENSP00000340672 | ENSP00000333934 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2- kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Armadillo repeat containing | tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs | 0.721 |
| ARMCX3 | ZCCHC10 | ENSP00000340672 | ENSP00000423276 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2- kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Armadillo repeat containing | Zinc finger CCHC-type containing 10 | 0.611 |
| CTDSPL2 | CXorf57 | ENSP00000260327 | ENSP00000361628 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | 0.599 |
| CTDSPL2 | FAM49B | ENSP00000260327 | ENSP00000429150 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | Protein FAM49B; Family with sequence similarity 49 member B | 0.607 |
| CTDSPL2 | TMEM135 | ENSP00000260327 | ENSP00000306344 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.674 |
| CTDSPL2 | ZCCHC10 | ENSP00000260327 | ENSP00000423276 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | Zinc finger CCHC-type containing 10 | 0.707 |
| CXorf57 | CTDSPL2 | ENSP00000361628 | ENSP00000260327 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | 0.599 |
| CXorf57 | FAM49B | ENSP00000361628 | ENSP00000429150 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | Protein FAM49B; Family with sequence similarity 49 member B | 0.537 |
| CXorf57 | TMEM135 | ENSP00000361628 | ENSP00000306344 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.605 |
| CXorf57 | ZCCHC10 | ENSP00000361628 | ENSP00000423276 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | Zinc finger CCHC-type containing 10 | 0.625 |
| FAM49B | CTDSPL2 | ENSP00000429150 | ENSP00000260327 | Protein FAM49B; Family with sequence similarity 49 member B | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | 0.607 |
| FAM49B | CXorf57 | ENSP00000429150 | ENSP00000361628 | Protein FAM49B; Family with sequence similarity 49 member B | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | 0.537 |
| FAM49B | TMEM135 | ENSP00000429150 | ENSP00000306344 | Protein FAM49B; Family with sequence similarity 49 member B | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.611 |
| FAM49B | ZCCHC10 | ENSP00000429150 | ENSP00000423276 | Protein FAM49B; Family with sequence similarity 49 member B | Zinc finger CCHC-type containing 10 | 0.676 |
| IMMP2L | ARMCX3 | ENSP00000384966 | ENSP00000340672 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2- kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Armadillo repeat containing | 0.682 |
| IMMP2L | LRRC19 | ENSP00000384966 | ENSP00000369395 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | Leucine-rich repeat-containing protein 19; Leucine rich repeat containing 19 | 0.712 |
| IMMP2L | TMEM214 | ENSP00000384966 | ENSP00000238788 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress; Belongs to the TMEM214 family | 0.722 |
